Ceriporic acid B, an extracellular metabolite of Ceriporiopsis subvermispora, suppresses the depolymerization of cellulose by the Fenton reaction.
Ceriporic acid B, an extracellular metabolite of Ceriporiopsis subvermispora, suppresses the depolymerization of cellulose by the Fenton reaction.
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DOI：
10.1021/bm050358t
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发表时间：
2005-08
影响因子：
6.2
通讯作者：
Noor Rahmawati;Y. Ohashi;Takahito Watanabe;Y. Honda;Takashi Watanabe
中科院分区：
文献类型：
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作者：
Noor Rahmawati;Y. Ohashi;Takahito Watanabe;Y. Honda;Takashi Watanabe
白腐菌（Ceriporiopsis subvermispora）能够降解木材中的木质素，而不会对纤维素造成严重损害。由于白腐菌对木质素的生物降解是通过自由基反应进行的，在铁离子、分子氧和H2O2存在的情况下，伴随着大量Fe3+-还原剂酚和还原性自由基的产生，因此人们提出C. subvermispora具有一个生物系统，通过芬顿反应抑制纤维素水解活性氧*OH的产生。在本文中，我们证明了C. subvermispora的胞外代谢物- 1- nonadec烯-2,3-二羧酸（ceriporic acid B）在铁离子、纤维素、H2O2和Fe3+还原剂对苯二酚（HQ）存在下，在真菌的生理pH值下，强烈抑制*OH的产生和纤维素的芬顿反应。
The white rot fungus, Ceriporiopsis subvermispora, is able to degrade lignin in wood without intensive damage to cellulose. Since lignin biodegradation by white rot fungi proceeds by radical reactions, accompanied by the production of a large amount of Fe3+-reductant phenols and reductive radical species in the presence of iron ions, molecular oxygen, and H2O2, C. subvermispora has been proposed to possess a biological system which suppresses the production of a cellulolytic active oxygen species, *OH, by the Fenton reaction. In the present paper, we demonstrate that 1-nonadecene-2,3-dicarboxylic acid (ceriporic acid B), an extracellular metabolite of C. subvermispora, strongly inhibited *OH production and the depolymerization of cellulose by the Fenton reaction in the presence of iron ions, cellulose, H2O2, and a reductant for Fe3+, hydroquinone (HQ), at the physiological pH of the fungus.