Reactive sulfur and selenium species in the regulation of bone homeostasis.
Reactive sulfur and selenium species in the regulation of bone homeostasis.
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DOI：
10.1016/j.freeradbiomed.2022.08.002
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发表时间：
2022-09
影响因子：
7.4
通讯作者：
Pluth, Michael D
中科院分区：
文献类型：
--
作者：
Gilbert, Annie K;Newton, Turner D;Hettiaratchi, Marian H;Pluth, Michael D
活性氧（Reactive oxygen species，ROS）是重要的生理信号调节剂，在骨组织调节中起重要作用。活性硫物质（RSS）和活性硒物质（RSeS）都参与ROS信号传导，最近的工作表明RSS和RSeS参与骨稳态的调节。例如，RSS可以促进成骨分化，降低破骨细胞活性和分化，并且RSeS的抗氧化活性在平衡骨重建中起关键作用。本文就RSS和RSeS在骨疾病和骨再生中的应用研究进展作一综述。专注于这些调查，我们强调不同的方法，工具，和RSS和RSeS的来源，我们还强调了未来的机会，提供RSS和RSeS在生物环境中有关骨。
Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved in ROS signaling, and recent work suggests RSS and RSeS involvement in the regulation of bone homeostasis. For example, RSS can promote osteogenic differentiation and decrease osteoclast activity and differentiation, and the antioxidant activity of RSeS play crucial roles in balancing bone remodeling. Here, we outline current research progress on the application of RSS and RSeS in bone disease and regeneration. Focusing on these investigations, we highlight different methods, tools, and sources of RSS and RSeS, and we also highlight future opportunities for delivery of RSS and RSeS in biological environments relating to bone.