Impaired learning of a motor skill in patients with Huntington's disease.
Impaired learning of a motor skill in patients with Huntington's disease.
复制标题
亨廷顿病患者的运动技能学习受损。
DOI：
10.1037//0735-7044.102.1.141
复制
发表时间：
1988
影响因子：
1.9
通讯作者：
Salmon,DP
中科院分区：
文献类型：
--
作者：
Heindel,WC;Butters,N;Salmon,DP
对亨廷顿氏病（HD）患者、阿尔茨海默氏型痴呆（DAT）患者和失忆症患者（AMN）获得运动技能的能力进行了评估。通过调整磁盘的旋转速度，两组在初始性能水平上的差异被最小化。HD组和DAT组还进行了言语识别广度测试。结果显示，DAT组、AMN组和完整对照组在六个测试块中都显著提高了他们在目标上的时间，而HD组在这项运动技能的习得方面严重受损。在言语识别广度测试中，DAT组和HD组同样显著受损，但HD组比DAT组表现出更好的即时和延迟回忆。这些结果提供了进一步的证据，表明基底神经节在运动技能的习得中起着关键作用。
The ability of patients with Huntington's disease (HD), patients with dementia of the Alzheimer's type (DAT), and amnesic patients (AMN) to acquire the motor skills underlying a pursuit rotor task was assessed. Differences between groups in initial levels of performance were minimized by adjusting the rotation speed of the disk. The HD and DAT groups were also administered a verbal recognition span test. The results showed that the DAT, AMN, and intact control groups all significantly improved their time on target over six test blocks whereas the HD group was severely impaired in the acquisition of this motor skill. On the verbal recognition span test, the DAT and HD groups were significantly and equally impaired, but the HD group evidenced better immediate and delayed recall than did the DAT group. These results provide further evidence that the basal ganglia are critically involved in the acquisition of motor skills.