Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas.
Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas.
复制标题
咖啡因剂量依赖性地增强顺铂对骨肉瘤的抗肿瘤作用。
作者：
M. Kawahara;Yuri Takahashi;Kotaro Takazawa;H. Tsuchiya;K. Tomita;K. Yokogawa;K. Miyamoto
背景
咖啡因辅助化疗已被用于治疗骨肉瘤。然而，几乎没有这种治疗的体内证据，因此我们试图验证咖啡因联合顺铂在骨肉瘤大鼠中的剂量和效果。
材料和方法
将7周龄雄性Fischer大鼠移植化学致癌剂诱导的骨肉瘤，选择肺转移病灶进行肿瘤块化。荷骨肉瘤大鼠接受生理盐水、咖啡因、顺铂或顺铂和咖啡因治疗。
结果
在联合给药组中观察到最大的生长抑制。当给予三种不同剂量的咖啡因时，肿瘤抑制程度与咖啡因的平均血浆浓度密切相关。当联合给予咖啡因时，肿瘤中的顺铂浓度显著增加。
结论
本研究证实，高浓度的咖啡因（约0.4 mM）可有效增强顺铂的抗肿瘤作用。
BACKGROUND
Caffeine-assisted chemotherapy has been used in the treatment of osteosarcomas. However, there is little in vivo evidence for this treatment, and thus we sought to verify the dose and effect of caffeine in combination with cisplatin in osteosarcoma-bearing rats.
MATERIALS AND METHODS
Seven-week-old male Fischer rats were transplanted with chemical carcinogen-induced osteosarcoma, selected lung metastatic lesions tumor block. The osteosarcoma-bearing rats were treated with saline, caffeine, cisplatin or cisplatin and caffeine.
RESULTS
The most growth inhibition was observed in the co-administration group. When three different dosing schedules of caffeine were given, the extent of tumor inhibition was closely correlated with the average plasma concentration of caffeine. The cisplatin concentration in the tumor was significantly increased when caffeine was co-administered.
CONCLUSION
This study confirms that a high concentration of caffeine (about 0.4 mM) is effective in enhancing the antitumor effects of cisplatin.
在用塞替派处理的人类癌细胞中，己酮可可碱在体内和体外增强了抗肿瘤作用。
影响因子：
11.2
作者：
Fingert,HJ;Pu,AT;Chen,ZY;Googe,PB;Alley,MC;Pardee,AB
通讯作者：
Pardee,AB