Maternal infections and subsequent psychosis among offspring
Maternal infections and subsequent psychosis among offspring
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DOI：
10.1001/archpsyc.58.11.1032
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发表时间：
2001-11-01
影响因子：
--
通讯作者：
Yolken, RH
中科院分区：
文献类型：
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作者：
Buka, SL;Tsuang, MT;Yolken, RH
背景资料：我们测试的假设，母亲在怀孕期间的感染与subs sequent发展的精神分裂症和其他精神病在adult.Methods：我们进行了巢式病例对照研究，27名成年人与精神分裂症和其他精神疾病和54匹配的未受影响的对照组（匹配的性别，种族和出生日期）从普罗维登斯，RI，队列的围产期合作项目。我们取回了这些母亲在怀孕结束时储存的血液样本。这些样本进行了分析总类特异性免疫球蛋白和特异性抗体针对公认的围产期病原体能够影响brain development.Results：母亲的IgG和IgM类免疫球蛋白的水平之前，他们的新生儿的母亲交付的情况下系列显着升高（IgG和IgM免疫球蛋白-白蛋白比值分别为t=3.06，P=.003; t=2.93，P=.004）。二次分析表明，母体单纯疱疹病毒2型糖蛋白gG 2抗体与随后的精神病之间存在显著相关性（匹配t检验=2.43，P= 0.02）。我们没有发现病例组和对照组母亲的血清伊加类免疫球蛋白水平，或单纯疱疹病毒1型、巨细胞病毒、弓形虫、风疹病毒、人细小病毒B19、沙眼衣原体或人乳头瘤病毒16型的特异性IgG抗体水平有显著差异。母亲总IgG和IgM免疫球蛋白以及单纯疱疹病毒2型抗体水平升高的后代患精神分裂症和其他精神病的风险增加。成年期的疾病
Background: We tested the hypothesis that maternal infections during pregnancy are associated with the subs equent development of schizophrenia and other psychoses in adulthood.Methods: We conducted a nested case-control study of 27 adults with schizophrenia and other psychotic illnesses and 54 matched unaffected control subjects (matched for sex, ethnicity, and date of birth) from the Providence, RI, cohort of the Collaborative Perinatal Project. We retrieved stored blood samples that had been obtained from these mothers at the end of pregnancy. These samples were analyzed for total class-specific immunoglobulins and for specific antibodies directed at recognized perinatal pathogens capable of affecting brain development.Results: Maternal levels of IgG and IgM class immunoglobulins before the mothers were delivered of their neonates were significantly elevated among the case series (t=3.06, P=.003; t=2.93, P=.004, respectively, for IgG and IgM immunoglobulin-albumin ratios). Secondary analyses indicated a significant association between maternal antibodies to herpes simplex virus type 2 glycoprotein gG2 and subsequent psychotic illness (matched t test=2.43, P=.02). We didn't find significant differences between case and control mothers in the serum levels of IgA class immunoglobulins, or in specific IgG antibodies to herpes simplex Virus type 1, cytomegalovirus, Toxoplasma gondii, rubella virus, human parvovirus B19, Chlamydia trachomatis, or human papillomavirus type 16.Conclusions: The offspring of mothers with elevated levels of total IgG and IgM immunoglobulins and antibodies to herpes simplex virus type 2 are at increased risk for the development of schizophrenia and other psychotic illnesses in adulthood.