Increased serum resistin level is associated with coronary heart disease
Increased serum resistin level is associated with coronary heart disease
复制标题
血清抵抗素水平升高与冠心病有关
DOI：
10.18632/oncotarget.15707
复制
发表时间：
2017-07-25
期刊：
影响因子：
--
通讯作者：
Xie, Xiang
中科院分区：
文献类型：
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作者：
Zhang, Jing-Zhan;Gao, Ying;Xie, Xiang
目的：探讨血清抵抗素水平与不同类型冠心病的关系。计算机检索PubMed、Web of Science、Google Scholar、Cochrane图书馆、万方数据、中国生物医学数据库、中国国家知识资源数据库，手工检索相关文献的参考文献列表。采用RevMan5.3统计软件进行处理和分析。共纳入22篇文献，涉及2070名受试者。Meta分析显示，稳定型心绞痛、不稳定型心绞痛和急性心肌梗死患者血清抵抗素水平显著高于正常对照组[SMD值(95%CI)分别为1.97(1.15，2.79)，2.54(1.76，3.31)，3.62(2.62，4.62，P均<0.00001)]。不稳定型心绞痛、急性心肌梗死患者血清抵抗素水平明显高于心绞痛组，分别为0.90，95CI(0.28，1.52，P=0.005)和2.28，95%CI(0.74，3.82，P=0.004)。急性心肌梗死患者血清抵抗素水平也高于不稳定型心绞痛患者[SMD1.22，95%CI(0.58，1.85)，P=0.0002]。研究表明，血清抵抗素水平升高与冠心病的严重程度显著相关。
To explore the relationship between the serum resistin level and different types of coronary heart diseases (CHD). Literature was retrieved by formal searching of PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, China Biological Medicine Database (SinoMed) and China National Knowledge Infrastructure (CNKI) and by hand searching of reference lists of related articles. RevMan5.3 statistical software was utilized for processing and analysis. A total of 22 literatures involving 2070 subjects were included. Meta-analysis showed that the level of serum resistin in the patients with stable angina (SA), unstable angina(UA) or acute myocardial infarction (AMI) were significantly higher than those of normal controls, respectively [SMD(95% CI) were 1.97(1.15, 2.79), 2.54(1.76, 3.31), and 3.62(2.62, 4.62), all P<0.00001]. Serum resistin level in patients with UA or AMI was higher than those in patients with SA, respectively [SMD=0.90, 95CI(0.28,1.52), P=0.005], [SMD=2.28, 95%CI(0.74, 3.82), P=0.004]. The level of serum resistin in patients with AMI was also higher than those in patients with UA [SMD=1.22, 95%CI(0.58, 1.85), P=0.0002]. The study demonstrated that increased serum resistin level is significantly associated with the severity of CHD.