Immunohistochemical and molecular subtypes of breast cancer in Nigeria
Immunohistochemical and molecular subtypes of breast cancer in Nigeria
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DOI：
10.1007/s10549-007-9694-5
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发表时间：
2008-07-01
影响因子：
3.8
通讯作者：
Akang, Effiong E.
中科院分区：
文献类型：
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作者：
Adebamowo, Clement A.;Famooto, Ayotunde;Akang, Effiong E.
目的以往的研究表明，大多数非洲人乳腺癌是激素受体阴性的，因此不同于其他人群的乳腺癌。我们决定评估在我们的实践中看到的患者的激素受体状态，看看他们是否确实与其他人群不同。方法：我们前瞻性地收集和分析了自2004年7月起18个月内到我们诊所就诊的连续患者的肿瘤。在此期间，我们观察了192例以前没有组织学诊断的患者，并对其肿瘤进行了常规组织学和免疫组织化学分析，以确定激素受体状态。结果65.1%的乳腺癌ER阳性，54.7%的乳腺癌PR阳性，79.7%的乳腺癌HER2阴性。管腔型A占77.6%，管腔型B占2.6%，基底型占15.8%，其余4.0%（6/152）为HER2 +/ER-亚型。我们发现激素受体状态与肿瘤分级相关，但与临床分期无关。结论：我们的结论是，有没有不同的激素受体的模式在乳腺癌患者的非洲起源相比，其他人群，并敦促更多的使用激素操作乳腺癌的管理在这一人群中。
Objective Previous studies suggest that the majority of breast cancer in Africans are hormone receptor negative and thus differ from breast cancer in other populations. We decided to evaluate the hormone receptor status of patients seen in our practice to see if they indeed differ from that of other populations. Methods We prospectively collected and analyzed tumors from consecutive patients presenting to our clinic over an 18 months period from July 2004. During the period, we saw 192 patients without previous histological diagnosis and conducted routine histological and immunohistochemical analysis of their tumors for hormone receptor status. Results Most, 65.1% of tumors were ER+, 54.7% were PR+ and 79.7% were HER2 negative. Majority of the tumors, 77.6% were luminal type A, 2.6% were luminal type B, 15.8% were basal type and the remaining 4.0% (6/152) were HER2+/ER- subtype. We found an association between hormone receptor status and tumor grade but not with stage at presentation. Conclusion We conclude that there is no difference in the pattern of hormone receptors in breast cancer patients of African origin compared to other populations and urge more use of hormone manipulation for management of breast cancer in this population.