Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys.
Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys.
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DOI：
10.1289/ehp154
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发表时间：
2016-11
影响因子：
10.4
通讯作者：
Hauser R
中科院分区：
文献类型：
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作者：
Burns JS;Lee MM;Williams PL;Korrick SA;Sergeyev O;Lam T;Revich B;Hauser R
二恶英、呋喃和多氯联苯 (PCB)、二恶英类和非二恶英类物质均与青春期的变化有关。我们在 8-9 岁入组的俄罗斯男孩中检查了这些化合物的青春期周围血清水平 [及其毒性当量 (TEQ)] 与青春期开始和成熟的关系，并前瞻性地跟踪了 17-18 岁的男孩。入组时，473 名男孩接受了血清二恶英类化合物和多氯联苯的检测。在基线访视时以及每年直到 17-18 岁，医生都会进行青春期分期 [生殖器 (G)、阴毛初露 (P) 和睾丸体积 (TV)]。 315 名受试者在 17-18 岁时完成了随访。青春期开始定义为 TV > 3 mL、G2 或 P2。性成熟定义为 TV ≥ 20 mL、G5 或 P5。多变量区间删失模型用于评估脂质标准化浓度与青春期时间的关联。二恶英类化合物、TEQ 和非二恶英类 PCB 总和的中位数（四分位距）分别为 362 pg/g 脂质（279-495）、21.1 pg TEQ/g 脂质（14.4-33.2）和 250 ng/g 脂质（164-395）。在调整后的模型中，与最低 TEQ 四分位数相比，最高 TEQ 四分位数与青春期开始较晚相关 [TV = 11.6 个月（95% CI：3.8，19.4）； G2 = 10.1 个月 (95% CI: 1.4, 18.8)] 和性成熟 [TV = 11.6 个月 (95% CI: 5.7, 17.6)； G5 = 9.7 个月（95% CI：3.1，16.2）]。然而，与非二恶英类 PCB 的最低四分位数相比，当与 TEQ 共同调整时，最高的四分位数与青春期提前 [TV = –8.3 个月 (95% CI:–16.2, –0.3)] 和性成熟 [TV = –6.3 个月 (95% CI:–12.2, –0.3)] 相关； G5 = –7.2 个月 (95% CI:–13.8, –0.6)]；仅当根据 TEQ 进行调整时，非二恶英类 PCB 关联才显着。 TEQ 和 PCB 与阴毛发育没有显着相关性。我们的结果表明，TEQ 可能会延迟男性青春期的时间，而非二恶英类 PCB 则会提前。 Burns JS, Lee MM, Williams PL, Korrick SA, Sergeyev O, Lam T, Revich B, Hauser R. 2016。俄罗斯男孩青春期前后血清二恶英和多氯联苯浓度与青春期时间的关联。环境健康视角124：1801–1807； http://dx.doi.org/10.1289/EHP154
Dioxins, furans, and polychlorinated biphenyls (PCBs), dioxin-like and non-dioxin-like, have been linked to alterations in puberty. We examined the association of peripubertal serum levels of these compounds [and their toxic equivalents (TEQs)] with pubertal onset and maturity among Russian boys enrolled at ages 8–9 years and followed prospectively through ages 17–18 years. At enrollment, 473 boys had serum dioxin-like compounds and PCBs measured. At the baseline visit and annually until age 17–18 years, a physician performed pubertal staging [genitalia (G), pubarche (P), and testicular volume (TV)]. Three hundred fifteen subjects completed the follow-up visit at 17–18 years of age. Pubertal onset was defined as TV > 3 mL, G2, or P2. Sexual maturity was defined as TV ≥ 20 mL, G5, or P5. Multivariable interval-censored models were used to evaluate associations of lipid-standardized concentrations with pubertal timing. Medians (interquartile ranges) of the sum of dioxin-like compounds, TEQs, and non-dioxin-like PCBs were 362 pg/g lipid (279–495), 21.1 pg TEQ/g lipid (14.4–33.2), and 250 ng/g lipid (164–395), respectively. In adjusted models, the highest compared to lowest TEQ quartile was associated with later pubertal onset [TV = 11.6 months (95% CI: 3.8, 19.4); G2 = 10.1 months (95% CI: 1.4, 18.8)] and sexual maturity [TV = 11.6 months (95% CI: 5.7, 17.6); G5 = 9.7 months (95% CI: 3.1, 16.2)]. However, the highest compared to the lowest quartile of non-dioxin-like PCBs, when co-adjusted by TEQs, was associated with earlier pubertal onset [TV = –8.3 months (95% CI:–16.2, –0.3)] and sexual maturity [TV = –6.3 months (95% CI:–12.2, –0.3); G5 = –7.2 months (95% CI:–13.8, –0.6)]; the non-dioxin-like PCB associations were only significant when adjusted for TEQs. TEQs and PCBs were not significantly associated with pubic hair development. Our results suggest that TEQs may delay, while non-dioxin-like PCBs advance, the timing of male puberty. Burns JS, Lee MM, Williams PL, Korrick SA, Sergeyev O, Lam T, Revich B, Hauser R. 2016. Associations of peripubertal serum dioxin and polychlorinated biphenyl concentrations with pubertal timing among Russian boys. Environ Health Perspect 124:1801–1807; http://dx.doi.org/10.1289/EHP154