Angiosarcomas of the head and neck: Clinical and pathologic characteristics
Angiosarcomas of the head and neck: Clinical and pathologic characteristics
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DOI：
10.1177/000348949710601110
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发表时间：
1997-11-01
影响因子：
1.4
通讯作者：
Suman, VJ
中科院分区：
文献类型：
--
作者：
Aust, MR;Olsen, KD;Suman, VJ
1974年至1992年，32例病理诊断为血管肉瘤的头部和颈部在我们的机构进行了评估。初步治疗组包括24例在我们机构首次诊断或确诊的患者，另外8例患者组成挽救组。有23名男性和9名女性。主要治疗组的中位年龄为63岁（范围18 - 91岁）。主要组患者的总体中位生存期为4.8年，3年生存率估计为57%（95%置信区间为39%至84%）。中位随访时间为2.1年（范围83天至9.7年）。肿瘤直径小于7.0 cm和肿瘤仅侵犯皮下组织的患者总体生存率更高，首次不良事件发生时间更长。二倍体DNA含量是至首次不良事件发生时间的显著有利预后因素。有丝分裂活性在两个终点均具有临界意义。肿瘤小于1.5 cm的患者仅通过手术成功治疗。接受联合手术和放射治疗的患者也往往表现更好。因为大多数区域复发的患者肿瘤大于7.0 cm，我们得出结论，这种大小的肿瘤患者在初次切除时进行区域颈淋巴结清扫或选择性颈部放疗可能会受益。
Between 1974 and 1992, 32 patients with pathologically diagnosed angiosarcoma of the head and neck were evaluated at our institution. The primary treatment group consisted of 24 patients who had the initial diagnosis made or confirmed at our institution, and the other 8 patients formed the salvage group. There were 23 men and 9 women. The median age in the primary treatment group was 63 years (range 18 to 91 years). The overall median survival among the primary group patients was 4.8 years, and the 3-year survival was estimated to be 57% (95% confidence interval 39% to 84%). The median follow-up was 2.1 years (range 83 days to 9.7 years). Patients who had tumors less than 7.0 cm in diameter and tumors with invasion only to the subcutaneous tissues had better overall survival and longer time to first adverse event. Diploid DNA content was a significant favorable prognostic factor for time to first adverse event. Mitotic activity was of borderline significance with both end points. Patients who had tumors of less than 1.5 cm were treated successfully with surgery alone. Patients treated with combined surgery and radiotherapy also tended to do better. Because most patients in whom regional recurrences developed had tumors larger than 7.0 cm, we conclude that patients with tumors of this size may benefit from regional neck node dissection at the time of primary excision or from elective neck irradiation.