Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder.
Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder.
复制标题
首发重度抑郁症患者尾状核和颞上回对基于努力的决策的反应减弱。
DOI：
10.1016/j.pnpbp.2015.07.006
复制
发表时间：
2016
影响因子：
5.6
通讯作者：
Chan Raymond C K
中科院分区：
文献类型：
--
作者：
Yang Xin-hua;Huang Jia;Lan Yong;Zhu Cui-ying;Liu Xiao-qun;Wang Ye-fei;Cheung Eric F C;Xie Guang-rong;Chan Raymond C K
研究背景快感缺失是重性抑郁症（MDD）的一个标志性特征，其神经生物学机制尚不清楚。本研究旨在探讨奖励相关的决策在MDD患者的神经机制。方法我们研究了行为和神经反应的奖励首次发作MDD患者（N = 25）和健康对照组（N = 25）使用的努力，支出奖励任务（EEfRT）。这项任务涉及对不同程度和概率的可能奖励的选择。我们测试了这一假设，即MDD患者将表现出减少的神经反应，在奖励相关的大脑结构参与成本效益decision-making.ResultsCompared with healthy controls. ResultsMDD患者显示出显着较弱的反应，在左侧尾状核时，对比的“高奖励”-“低奖励”的条件，当对比高概率和低概率时，左侧上级颞回和右侧尾状核的反应变钝。此外，硬任务选择在高概率试验呈负相关，上级颞回活动在MDD患者，而同样的选择呈负相关，尾状核活动在healthcontrols.ConclusionsThese结果表明，减少尾状核和上级颞回激活可能会支持异常的成本效益决策MDD。
BackgroundAnhedonia, the loss of interest or pleasure in reward processing, is a hallmark feature of major depressive disorder (MDD), but its underlying neurobiological mechanism is largely unknown. The present study aimed to examine the underlying neural mechanism of reward-related decision-making in patients with MDD.MethodWe examined behavioral and neural responses to rewards in patients with first-episode MDD (N = 25) and healthy controls (N = 25) using the Effort-Expenditure for Rewards Task (EEfRT). The task involved choices about possible rewards of varying magnitude and probability. We tested the hypothesis that individuals with MDD would exhibit a reduced neural response in reward-related brain structures involved in cost–benefit decision-making.ResultsCompared with healthy controls, patients with MDD showed significantly weaker responses in the left caudate nucleus when contrasting the ‘high reward’–‘low reward’ condition, and blunted responses in the left superior temporal gyrus and the right caudate nucleus when contrasting high and low probabilities. In addition, hard tasks chosen during high probability trials were negatively correlated with superior temporal gyrus activity in MDD patients, while the same choices were negatively correlated with caudate nucleus activity in healthy controls.ConclusionsThese results indicate that reduced caudate nucleus and superior temporal gyrus activation may underpin abnormal cost–benefit decision-making in MDD.