The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia
The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia
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DOI：
10.1016/s0893-133x(99)00096-2
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发表时间：
2000-02-01
影响因子：
7.6
通讯作者：
Weiberger, DR
中科院分区：
文献类型：
--
作者：
Bertolino, A;Breier, A;Weiberger, DR
精神分裂症与多巴胺功能异常有关，最近与安非他明诱导的纹状体多巴胺过度释放有关，也与前额叶皮质神经元的病理学有关。据推测，前额叶病变是导致多巴胺失调的主要条件。我们在体内评估了精神分裂症患者和健康受试者的背外侧前额叶皮层神经元完整性（用质子磁共振光谱成像测量N-乙酰天冬氨酸（NAA）相对浓度）与安非他明诱导的纹状体多巴胺释放（用C-11-雷氯必利正电子发射断层扫描（PET）评估）之间的关系。在患者中，背外侧前额叶皮层的NAA测量选择性地预测了苯丙胺输注后C-11-雷氯必利的纹状体移位（rho =-0.76，p
Schizophrenia has been linked to abnormal dopamine function, recently to excessive amphetamine-induced release of striatal dopamine, and also to pathology of prefrontal cortical neurons. It has been hypothesized that prefrontal pathology is a primary condition that leads to dopamine dysregulation. We evaluated in vivo the relationship between neuronal integrity in dorsolateral prefrontal cortex, assessed as N-acetylaspartate (NAA) relative concentrations measured with proton magnetic resonance spectroscopic imaging, and amphetamine-induced release of striatal dopamine, assessed with C-11-raclopride Positron Emission Tomography (PET) in patients wi;fh schizophrenia and in healthy subjects. In the patients, NAA measures in dorsolateral prefrontal cortex selectively predicted striatal displacement of C-11-raclopride after amphetamine infusions (rho = -0.76, p