Neurological update: use of cardiac troponin in patients with stroke.

Neurological update: use of cardiac troponin in patients with stroke.
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神经系统更新:中风患者心脏肌钙蛋白的使用。

DOI:
10.1007/s00415-020-10349-w
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发表时间:
2021-06
影响因子:
6
通讯作者:
Endres M
Endres M
中科院分区:
医学2区
文献类型:
--
作者:
Scheitz JF;Stengl H;Nolte CH;Landmesser U;Endres M

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心肌肌钙蛋白是识别和定量心肌损伤的特异性和敏感性生物标志物。急性缺血性卒中后经常检测到心肌损伤,并与不良结局密切相关。伴随急性冠状动脉综合征只是可能导致卒中后心肌肌钙蛋白升高的几种鉴别诊断之一。因此,在临床实践中,对伴有心肌损伤的卒中患者的正确解释和最佳管理存在不确定性。心肌肌钙蛋白升高可能是“中风-心脏综合征”的一部分。术语“中风-心脏综合征”包括中风后心脏并发症的临床谱,包括心脏损伤、功能障碍和心律失常,其可能与自主神经功能和脑-心轴紊乱有关。在这篇综述中,我们提供了一个最新的概述,对急性缺血性卒中患者心肌肌钙蛋白水平升高的预后意义,机制和管理。
Cardiac troponin is a specific and sensitive biomarker to identify and quantify myocardial injury. Myocardial injury is frequently detected after acute ischemic stroke and strongly associated with unfavorable outcomes. Concomitant acute coronary syndrome is only one of several possible differential diagnoses that may cause elevation of cardiac troponin after stroke. As a result, there are uncertainties regarding the correct interpretation and optimal management of stroke patients with myocardial injury in clinical practice. Elevation of cardiac troponin may occur as part of a ‘Stroke-Heart Syndrome’. The term ‘Stroke-Heart Syndrome’ subsumes a clinical spectrum of cardiac complications after stroke including cardiac injury, dysfunction, and arrhythmia which may relate to disturbances of autonomic function and the brain–heart axis. In this review, we provide an up-to-date overview about prognostic implications, mechanisms, and management of elevated cardiac troponin levels in patients with acute ischemic stroke.
DOI: 10.1161/strokeaha.119.028323
发表时间: 2020-04-01
期刊: STROKE
影响因子: 8.3
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