Antiserum raised against the Epstein-Barr virus BARF0 protein reacts to HLA-DR β chain
Antiserum raised against the Epstein-Barr virus BARF0 protein reacts to HLA-DR β chain
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针对 Epstein-Barr 病毒的抗血清 BARF0 蛋白与 HLA-DR β 链发生反应
DOI：
10.1007/s007050200021
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发表时间：
2002
影响因子：
2.7
通讯作者：
T. Sculley
中科院分区：
文献类型：
--
作者：
W. Schroder;N. Kienzle;G. Bushell;T. Sculley
病毒在鼻咽癌和伯基特淋巴瘤中所起的作用多年来一直处于深入研究之中。由于在这些肿瘤中只有一组有限的病毒基因表达，因此很难理解病毒如何导致/帮助肿瘤的产生。1997年，Fries等人发表了一篇论文。[Fries et al.(1997)鉴定了EB病毒BamHI A区编码的一种新蛋白。J Virol 71：2765-2771。]其中产生兔血清并用于鉴定从EBV的BamH1A区编码的蛋白产物(RK-BARF0)。在本文中，我们从二维凝胶中分离了这些蛋白质，并用质谱仪鉴定了它们是人类白细胞抗原DR的组成成分。
Summary. The role that Epstein-Barr virus plays in nasopharyngeal carcinoma and Burkitt’s lymphoma has been under intense study for many years. With only a limited set of viral genes being expressed in these tumours it has been difficult to understand how the virus could cause/aid in the generation of the tumours. In 1997 a paper was published by Fries et al. [Fries et al. (1997) Identification of a novel protein encoded by the BamHI A region of the Epstein-Barr virus. J Virol 71: 2765–2771.] in which a rabbit serum was generated and used to identify protein products (RK-BARF0) encoded from the BamH1 A region of EBV. In this paper we have isolated these proteins from two-dimensional gels and identified them, using mass spectrometry, as components of HLA DR.
影响因子：
56.9
作者：
Uchida, J;Yasui, T;Kikutani, H
通讯作者：
Kikutani, H