MUTANT ALLELES AT THE LOCUS ELAV IN DROSOPHILA-MELANOGASTER LEAD TO NERVOUS-SYSTEM DEFECTS - A DEVELOPMENTAL GENETIC-ANALYSIS
MUTANT ALLELES AT THE LOCUS ELAV IN DROSOPHILA-MELANOGASTER LEAD TO NERVOUS-SYSTEM DEFECTS - A DEVELOPMENTAL GENETIC-ANALYSIS
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DOI：
10.3109/01677068509100150
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发表时间：
1985-01-01
影响因子：
1.9
通讯作者：
WHITE, K
中科院分区：
文献类型：
--
作者：
CAMPOS, AR;GROSSMAN, D;WHITE, K
利用X连锁遗传分析法对D.黑腹菌该基因座位于唾液带区域1B 4 -5至1B 8 -9，这是X染色体的一部分，以前被证明对正常神经发育至关重要。该基因座的某些突变等位基因可导致胚胎致死，表明该基因提供的功能在胚胎发生过程中是必不可少的。雌雄同体的遗传嵌合体的发育分析表明：基因的功能是自主的眼睛是必不可少的，基因的功能是必要的视叶的正常发育和基因的功能是不必要的，在大多数主要的椎间盘细胞衍生物的眼睛盘除外。温度敏感等位基因发育分析的结论与嵌合体分析的结果一致。由突变等位基因和在遗传嵌合体中观察到的异常引起的胚胎致死性使我们将位点l（1）EC 7重命名为elav（胚胎致死，异常视觉系统）。
A developmental and genetic analysis of the X-linked vital locus l(1)EC7 in D. melanogaster. The locus maps in the salivary band region 1B4-5 to 1B8-9, a part of the X chromosome previously shown to be essential for normal neural development. Certain mutant alleles at the locus can cause embryonic lethality, indicating that the function provided by the gene is essential during embryogenesis. A developmental analysis of gynandromorphic genetic mosaics shows that: the gene function is autonomously essential in the eye; the gene function is essential for normal development of the optic lobes and the gene function is not necessary in most major imaginal-disc cell derivatives with the exception of the eye disc. Conclusions from the developmental analysis of a temperature sensitive allele are consistent with those from the mosaic analysis. The embryonic lethality caused by the mutant alleles and abnormalities observed in the genetic mosaics have led us to rename the locus l(1)EC7 to elav (embryonic lethal, abnormal visual system).