Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC
Characterization of grlA, grlB, gyrA, and gyrB mutations in 116 unrelated isolates of Staphylococcus aureus and effects of mutations on ciprofloxacin MIC
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DOI：
10.1128/aac.42.5.1249
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发表时间：
1998-05-01
影响因子：
4.9
通讯作者：
Köhrer, K
中科院分区：
文献类型：
--
作者：
Schmitz, FJ;Jones, ME;Köhrer, K
研究了来自 8 个国家的 116 株无关的金黄色葡萄球菌临床分离株（70 株对环丙沙星耐药，46 株对环丙沙星敏感）的 grlA、grlB、gyrA 和 gyrB 基因位点是否存在突变。 grlA 内的两个突变（位于密码子 80 和 84）和 gyrA 内的两个突变（位于密码子 84 和 88）明显与环丙沙星耐药性相关，尽管在研究的四个基因内检测到的其他突变也可能导致敏感性降低。
One hundred sixteen unrelated clinical isolates of Staphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations in the grlA, grlB, gyrA, and gyrB gene loci. Two mutations within grlA (located at codons 80 and 84) and two mutations within gyrA (located at codons 84 and 88) were clearly associated with ciprofloxacin resistance, although other mutations detected within the four genes studied may also contribute to decreased susceptibility.