ASPERGILLUS-FUNGEMIA - REPORT OF 2 CASES AND REVIEW
ASPERGILLUS-FUNGEMIA - REPORT OF 2 CASES AND REVIEW
复制标题
DOI：
10.1093/clinids/20.3.598
复制
发表时间：
1995-03-01
影响因子：
11.8
通讯作者：
DENNING, DW
中科院分区：
文献类型：
--
作者：
DUTHIE, R;DENNING, DW
我们提出了两例经血培养证实的曲霉菌感染，并回顾了其他30例真正的曲霉菌血症和34例曲霉菌假真菌血症。使用多种不同的培养基和血培养系统来分离曲霉。在真正的病例中，血培养阳性的中位时间为8.5天（范围，1-27天）。与其他情况相比，在心脏手术后（n = 11 [34%]）或中性粒细胞减少症期间（n = 9 [28%]）更常观察到真正的曲霉菌血症。在最近的一系列中性粒细胞减少症期间的真菌血症中，7.6%的发作是由于曲霉菌。其他有曲霉菌血症风险的患者与有侵袭性曲霉病风险的患者相似，包括艾滋病患者。19例接受治疗的患者中有7例（44%）存活。在曲霉菌性假真菌血症患者组中，无死亡病例，同一患者的其他标本培养结果均为阴性。标准，可适用于确定是否从血培养分离曲霉菌是临床意义的提出。
We present two cases of aspergillus infection confirmed by blood culture and review 30 other cases of genuine aspergillus fungemia and 34 cases of aspergillus pseudofungemia. Multiple different media and blood culture systems were used to isolate Aspergillus. The median time to positive blood culture was 8.5 days (range, 1-27 days) in the genuine cases. Genuine aspergillus fungemia was observed more often after cardiac surgery (n = 11 [34%]) or during neutropenia (n = 9 [28%]) than in other settings. In a recent series of fungemia during neutropenia, 7.6% of all episodes were due to Aspergillus. Other patients at risk for aspergillus fungemia were similar to those at risk for invasive aspergillosis, including patients with AIDS. Seven (44%) of 19 patients who were treated survived. In the group of patients with aspergillus pseudofungemia, there were no deaths, and cultures of additional specimens from the same patient were not positive. Criteria that may be applied to ascertain whether the isolation of Aspergillus from blood cultures is clinically significant are put forward.