New Amino-protective Reagents for t-Butoxycarbonylation and Benzyloxycarbonylation of Amines and Amino Acids
New Amino-protective Reagents for t-Butoxycarbonylation and Benzyloxycarbonylation of Amines and Amino Acids
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用于胺和氨基酸的叔丁氧基羰基化和苄氧基羰基化的新型氨基保护试剂
DOI：
10.1246/bcsj.58.3570
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
K. Yi
中科院分区：
文献类型：
--
作者：
Sunggak Kim;Jae In Lee;K. Yi
开发了用于胺和氨基酸的t-丁氧羰基化和苯氧羰基化的新型氨基保护试剂。2-吡啶基碳酸t-丁酯和S-（2-吡啶基）硫代碳酸t-丁酯与多种胺和氨基酸反应，生成N-Boc胺和N-Boc氨基酸，产率高。2-吡啶基碳酸苄酯和o -苄基S-（2-吡啶基）硫代碳酸酯也被发现在氨基酸的苯氧羰基化中非常有效。
New amino-protective reagents for t-butoxycarbonylation and benzyloxycarbonylation of amines and amino acids have been developed. t-Butyl 2-pyridyl carbonate and t-butyl S-(2-pyridyl) thiocarbonate react cleanly with various amines and amino acids to afford N-Boc amines and N-Boc amino acids in high yields. Benzyl 2-pyridyl carbonate and O-benzyl S-(2-pyridyl) thiocarbonate are also found to be very effective in the benzyloxycarbonylation of amino acids.