Bioinspired Networks of Communicating Synthetic Protocells.
Bioinspired Networks of Communicating Synthetic Protocells.
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DOI：
10.3389/fmolb.2021.804717
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发表时间：
2021
影响因子：
5
通讯作者：
Gobbo P
中科院分区：
文献类型：
--
作者：
Grimes PJ;Galanti A;Gobbo P
从无生命的分子和材料中自下而上合成细胞样实体或原始细胞是我们这个时代的重大挑战之一。在过去的十年中，自下而上合成生物学新兴领域的研究人员开发了不同的原始细胞模型，并对其进行了改造，以模仿生物细胞的一种或多种能力，如信息转录和翻译，粘附和酶介导的代谢。虽然迄今为止的努力集中在增加单个原始细胞的生化复杂性，但自下而上合成生物学的一个新挑战是开发通信合成原始细胞的网络。设计能够发送和接收化学信号以触发个人或集体编程细胞样行为或与活细胞和组织通信的多原细胞系统的可能性将导致重大科学突破，在生物技术、组织工程和再生医学方面具有重要应用。这篇迷你评论将讨论自下而上合成生物学的这一新的新兴领域，并将介绍最近出现的三种生物启发的合成原始细胞通信网络。
The bottom-up synthesis of cell-like entities or protocells from inanimate molecules and materials is one of the grand challenges of our time. In the past decade, researchers in the emerging field of bottom-up synthetic biology have developed different protocell models and engineered them to mimic one or more abilities of biological cells, such as information transcription and translation, adhesion, and enzyme-mediated metabolism. Whilst thus far efforts have focused on increasing the biochemical complexity of individual protocells, an emerging challenge in bottom-up synthetic biology is the development of networks of communicating synthetic protocells. The possibility of engineering multi-protocellular systems capable of sending and receiving chemical signals to trigger individual or collective programmed cell-like behaviours or for communicating with living cells and tissues would lead to major scientific breakthroughs with important applications in biotechnology, tissue engineering and regenerative medicine. This mini-review will discuss this new, emerging area of bottom-up synthetic biology and will introduce three types of bioinspired networks of communicating synthetic protocells that have recently emerged.