Immunologic Profiles of Persons Recruited for a Randomized, Placebo-Controlled Clinical Trial of Hookworm Infection
Immunologic Profiles of Persons Recruited for a Randomized, Placebo-Controlled Clinical Trial of Hookworm Infection
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DOI：
10.4269/ajtmh.2009.09-0237
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发表时间：
2009-11-01
影响因子：
3.3
通讯作者：
Pritchard, David
中科院分区：
文献类型：
--
作者：
Blount, Daniel;Hooi, Doreen;Pritchard, David
流行病学研究的数据表明，钩虫感染，在建立一个免疫表型有利于寄生虫生存，可以防止过敏性疾病的发展。我们描述了一项临床研究的免疫学结果，该研究旨在调查过敏性鼻炎患者医源性钩虫感染的安全性。本研究中使用的较低、相对安全水平的钩虫感染具有免疫原性，可诱导嗜酸性粒细胞增多和显著的特异性IgG应答。重要的是，没有看到参与者对环境过敏原的IgE反应增强。然而，在感染的参与者中没有发现全身免疫调节的证据。这一发现可能表明，在未来的试验中，感染的水平或感染的频率可能必须改变，以诱导治疗有益的免疫表型。
Data from epidemiologic studies suggest that hookworm infections, in establishing an immunologic phenotype conducive to parasite survival, may protect against the development of allergic disease. We describe immunologic findings front a clinical study designed to investigate the safety of iatrogenic hookworm infection in participants with allergic rhinitis. The low, relatively safe level of hookworm infection used in this study was immunogenic, inducing eosinophilia and a significant specific IgG response. Importantly, no potentiation of IgE responses to the environmental allergens to which the participants were sensitized was seen. However, no evidence of systemic immune regulation was seen in infected participants. This finding may indicate that the level of infection or the frequency of infection may have to be altered in future trials to induce a therapeutically conducive immunologic phenotype.