The potential long-term effect of previous schistosome infection reduces the risk of metabolic syndrome among Chinese men
The potential long-term effect of previous schistosome infection reduces the risk of metabolic syndrome among Chinese men
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DOI：
10.1111/pim.12187
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发表时间：
2015-07-01
影响因子：
2.2
通讯作者：
Tong, D. -X.
中科院分区：
文献类型：
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作者：
Shen, S. -W.;Lu, Y.;Tong, D. -X.
既往血吸虫感染(PSI)的潜在长期影响与代谢综合征的发展之间的关联尚不清楚。因此，我们的目标是评估它们之间的关联。参与者来自40年前中国严重流行日本血吸虫病的地区。1,597人被征召入伍。其中，465例PSI患者为研究对象，1132例为对照组。我们发现PSI与代谢综合征及其组成部分(包括中心性肥胖、高甘油三酯血症和低高密度脂蛋白胆固醇)的较低患病率显著相关，这表明PSI的潜在长期效应可能降低代谢综合征的风险。然而，PSI的保护性免疫作用还需要进一步的研究。
The association between potential long-term effects of previous schistosome infection (PSI) and the development of metabolic syndrome remains unknown. Therefore, we aimed to evaluate the association between them. Participants were from regions which were all reportedly heavily endemic for S.japonicum in China 40years ago. One thousand five hundred and ninety-seven men were enrolled. Among these, 465 patients with PSI were selected as study subjects and 1132 subjects served as controls. We found PSI significantly correlated with lower prevalences of metabolic syndrome and its components, including central obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol, which indicates that the potential long-term effects of PSI may reduce the risk of metabolic syndrome. However, further studies are needed to investigate the protective immune effects of PSI.