PET/MR: Yet another Tesla?
PET/MR: Yet another Tesla?
复制标题
正电子发射断层扫描/磁共振成像（PET/MR）：又一个“特斯拉”式的创新？
DOI：
10.1007/s12350-016-0665-2
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发表时间：
2017-06-01
影响因子：
2.4
通讯作者：
Nekolla, Stephan G.
中科院分区：
文献类型：
--
作者：
Schwaiger, Markus;Kunze, Karl;Nekolla, Stephan G.
在PET/CT作为一种多模态成像技术成功引入之后，PET/MR随后成为神经病学、肿瘤学和心脏病学应用的一种有吸引力的仪器。结合结构、功能和分子成像的同步数据采集提供了一个独特的平台，可以将心脏表现的各个方面联系起来，以实现心血管疾病表型的非侵入性表征。具体来说，通过MR技术进行组织表征，无论是否使用造影剂，都可以获得功能参数，如LGE、心肌灌注和T1图，以及细胞外体积的估计。PET示踪剂以其高灵敏度和特异性而著称，从而补充了MRI的功能性组织表征。尽管临床应用尚未得到验证，但PET/MR的首次经验表明，它将在血管成像（不稳定斑块）领域以及涉及心脏的炎症过程的表征中应用。缺血性心脏病可以通过综合区域功能、灌注和生存能力来综合评估。未来的技术改进将降低PET/MR仪器的成本，以支持这项有前途的技术在心脏病学中的常规临床应用。
After the successful introduction of PET/CT as a multimodality imaging technique, PET/MR has subsequently emerged as an attractive instrumentation for applications in neurology, oncology, and cardiology. Simultaneous data acquisition combining structural, functional, and molecular imaging provides a unique platform to link various aspects of cardiac performance for the non-invasive characterization of cardiovascular disease phenotypes. Specifically, tissue characterization by MR techniques with and without contrast agents allows for functional parameters such as LGE, myocardial perfusion, and T1 maps as well as an estimate of extracellular volume. PET tracers excel by their high sensitivity and specificity, thus supplementing the functional tissue characterization by MRI. Although the clinical applications are yet to be validated, the first experience with PET/MR suggests future applications in the area of vascular imaging (unstable plaque) as well as in the characterization of inflammatory processes involving the heart. Ischemic heart disease can be comprehensively assessed by integrating regional function, perfusion, and viability. Future technical improvements leading to less costly PET/MR instrumentation are necessary to support routine clinical application of this promising technique in cardiology.