SPATIAL-DISTRIBUTION OF MUSCLE-FIBERS WITHIN THE TERRITORY OF A MOTOR UNIT
SPATIAL-DISTRIBUTION OF MUSCLE-FIBERS WITHIN THE TERRITORY OF A MOTOR UNIT
复制标题
DOI：
10.1002/mus.880131208
复制
发表时间：
1990-12-01
期刊：
影响因子：
3.4
通讯作者：
EDGERTON, VR
中科院分区：
文献类型：
--
作者：
BODINEFOWLER, S;GARFINKEL, A;EDGERTON, VR
在成年猫的比目鱼肌 (SOL) 和胫骨前肌 (TA) 中研究了属于运动单位的肌纤维的空间分布，以提供运动单位范围内存在的空间模式的详细描述。运动单位的糖原消耗是通过重复刺激细胞内识别的运动神经元或功能上分离的运动轴突来实现的。在连续横截面中识别属于受刺激单元的肌纤维，并在包含最耗尽纤维的横截面中确定每个耗尽纤维的质心。随后，使用三个空间分析，即样方分析、点到最近邻分析和纤维间距离分析来确定运动单元纤维是否在整个单元区域中随机分布。运动单位纤维往往位于肌肉横截面内，并且在整个区域内分布不均匀或均匀。一般来说，分析表明运动单位纤维可能排列成不同大小的簇或亚组。这些数据展示了用于研究正常运动单位肌纤维组织的三种不同的定量分析，可用于神经肌肉疾病的客观评估和诊断。
The spatial distribution of muscle fibers belonging to a motor unit was studied in the soleus (SOL) and tibialis anterior (TA) of adult cats to provide a detailed description of the spatial patterns which exist within the territory of a motor unit. Glycogen depletion of the motor unit was achieved through repetitive stimulation of either the intracellularly identified motoneuron or the functionally isolated motor axon. Muscle fibers belonging to the stimulated unit were identified in serial cross-sections, and in the cross-section which contained the most depleted fibers the centroid of each depleted fiber was determined. Subsequently, three spatial analyses, ie, a quadrat analysis, a point-to nearest neighbor analysis and an interfiber distance analysis, were used to determine if motor unit fibers were distributed randomly throughout the territory of the unit. Motor unit fibers tended to be localized within the muscle cross-section and were not evenly or homogeneously distributed throughout the territory. In general, the analyses suggested that motor unit fibers may be arranged in clusters or subgroups of varying size. The data demonstrate three different quantitative analyses for studying the organization of muscle fibers of normal motor units, which can be used for ojective assessment and diagnosics of neuromuscular diseases.