Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20 years-old girls:: lack of association
Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20 years-old girls:: lack of association
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DOI：
10.1046/j.1365-2796.1998.00302.x
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发表时间：
1998-05-01
影响因子：
11.1
通讯作者：
Steingrimsdottir, L
中科院分区：
文献类型：
--
作者：
Kristinsson, JÖ;Valdimarsson, Ö;Steingrimsdottir, L
Objective.维生素D缺乏症已被证明与中老年妇女的低骨密度有关。这项研究的目的是评估这种关联是否可能存在于青春期和年轻成年女孩，接近峰值骨量。横截面研究在冬末进行。雷克雅未克地区北纬64度。从雷克雅未克的登记处随机选择了259名年龄分别为16岁、18岁和20岁的冰岛白人女孩。采用双能X线骨密度仪（DEXA）测量腰椎、髋部、前臂远端和整个骨骼的骨密度，并与放射免疫法测定的血清25-羟基维生素D [25（OH）D]水平进行比较。钙和维生素D的摄入量也进行了评估。18.5%的女孩血清25（OH）D低于25 nmol L ~（-1），这已被公认为成人的正常下限。25（OH）D水平与骨密度无显著相关性。正常的钙和磷酸盐浓度和正常的骨矿物质密度维持在青少年和年轻的成年女孩在较低的25（OH）D水平比发表的“正常”水平的中年和老年人。
Objective. Hypovitaminosis D has been shown to be associated with low bone mineral density in middle-aged and elderly women. The aim of this study was to evaluate whether such an association might exist in adolescent and young adult girls, approaching peak bone mass.Design. Cross-sectional study carried out in late winter.Setting. Reykjavik area at latitude 64 degrees N.Subjects. Two-hundred and fifty-nine Icelandic Caucasian girls, aged 16, 18 and 20 years, randomly selected from the registry of Reykjavik.Main outcome measures. Bone mineral density in lumbar spine, hip, distal forearm and total skeleton was measured with dual-energy X-ray absorptiometry (DEXA) and compared with 25-hydroxyvitamin D levels [25 (OH)D] in serum, measured by radioimmunoassay. Calcium and vitamin-D intake were also assessed by a questionnaire.Results. 18.5% of the girls were below 25 nmol L-1 in serum 25 (OH)D which has been recognized as the lower normal limit for adults. No significant association was found between 25 (OH)D levels and bone mineral density.Conclusions. Normal calcium and phosphate concentrations in plasma and normal bone mineral density are maintained in adolescent and young adult girls at lower 25 (OH)D levels than published 'normal' levels for middle-aged and elderly.