Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention.
Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention.
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DOI：
10.1007/s40495-017-0106-1
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发表时间：
2017-12
影响因子：
--
通讯作者：
Zi X
中科院分区：
文献类型：
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作者：
Li Y;Pham V;Bui M;Song L;Wu C;Walia A;Uchio E;Smith-Liu F;Zi X
红景天提取物已被用作健康人群的膳食补充剂，包括运动员，以非特异性地增强身体对身体和行为压力的自然抵抗力，以对抗疲劳和抑郁。本文就红景天提取物的新药理活性及其分子机制进行综述。除了具有多重的应激保护作用外，红景天提取物最近在不同的模型系统中显示出抗衰老、抗炎症、免疫刺激、DNA修复和抗癌作用。本文主要研究了红景天提取物的分子机制及其生物活性成分红景天苷。红景天提取物和红景天苷在抗癌和正常生理功能方面具有不同的分子机制。对于癌症，红景天提取物和红景天苷通过下调HIF-1α/HIF-2α的表达抑制mTOR通路，减少血管生成。对于正常生理功能，红景天提取物和红景天苷通过抑制骨骼肌PHD3和稳定HIF-1α蛋白，激活mTOR通路，刺激旁分泌功能，促进新生血管形成。与许多天然化合物相比，红景天苷是水溶性的，通过口服给药具有很高的生物利用度，并通过肾脏排泄在尿液中浓缩。红景天提取物和红景天苷对细胞和系统的益处类似于积极的生活方式干预对正常生理功能和抗癌的影响。红景天提取物或红景天苷的独特药理特性值得进一步研究，用于癌症化学预防，特别是人类膀胱癌。
Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’s action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through down-regulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.