One-carbon metabolism and epigenetics: understanding the specificity.
One-carbon metabolism and epigenetics: understanding the specificity.
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DOI：
10.1111/nyas.12956
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发表时间：
2016-01
影响因子：
5.2
通讯作者：
Locasale JW
中科院分区：
文献类型：
--
作者：
Mentch SJ;Locasale JW
单碳代谢是一个代谢网络，它整合了来自环境的营养状态，从而产生多种生物功能。它由叶酸和蛋氨酸循环组成，产生s -腺苷蛋氨酸（SAM）， SAM是甲基化反应的通用甲基供体，包括组蛋白和DNA甲基化。组蛋白甲基化是表观遗传密码的重要组成部分，并在染色质状态的建立中发挥多种作用，介导基因表达的调节。组蛋白甲基转移酶（hmt）的活性依赖于细胞内SAM的水平，SAM的水平根据细胞营养物质的可用性而波动，这在细胞代谢和组蛋白甲基化之间提供了联系。在此，我们讨论组蛋白甲基转移酶的生化特性和基因调控及其与细胞代谢的联系。我们的重点是理解这种有趣联系的特殊性。
One carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. Composed of the folate and methionine cycle, it generates S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of and gene regulation by histone methyltransferases and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.