Motor activity (exploration) and formation of home bases in mice (C57BL/6) influenced by visual and tactile cues: Modification of movement distribution, distance, location, and speed
Motor activity (exploration) and formation of home bases in mice (C57BL/6) influenced by visual and tactile cues: Modification of movement distribution, distance, location, and speed
复制标题
DOI：
10.1016/j.physbeh.2006.01.026
复制
发表时间：
2006-04-15
影响因子：
2.9
通讯作者：
Whishaw, IQ
中科院分区：
文献类型：
--
作者：
Clark, BJ;Hamilton, DA;Whishaw, IQ
组织小鼠在“探索”测试中的运动活动。小鼠建立家庭基地，在操作上定义为它们花费很长时间的地方，靠近它们进行短途旅行的物理对象和筑巢材料。这个组织提出了一个问题，即小鼠运动活动在多大程度上受到先天倾向与环境影响的调节。在这里，上下文线索（视觉和触觉）对C57 BL/6小鼠的运动活动的影响进行了检查：（1）在没有墙壁，部分墙壁或完整墙壁的开放场地上，（2）在存在不同的视觉线索，房间线索，或在没有视觉线索（红外光）的情况下，和（3）在存在视觉和触觉线索的配置。老鼠在有明显线索的情况下通常不那么活跃，并在这些线索附近形成了基地。此外，运动速度，路径分布，和停止的数量和长度调制的上下文线索。通过反复的测试，老鼠更喜欢触觉线索而不是视觉线索作为它们的大本营。虽然在测试日对线索的反应是强大的，但对上下文的条件反射一般都很弱。小鼠的探索行为受经验和背景的影响，提供了对性能变异性的见解，并可能在调查遗传和神经对小鼠行为的影响方面证明是有用的。(c)2006年爱思唯尔公司All rights reserved.
The motor activity of mice in tests of "exploration" is organized. Mice establish home bases, operationally defined as places where they spend long periods of time, near physical objects and nesting material from which they make excursions. This organization raises the question of the extent to which mouse motoric activity is modulated by innate predispositions versus environmental influences. Here the influence of contextual cues (visual and tactile) on the motor activity of C57BL/6 mice was examined: (1) on an open field that had no walls, a partial wall, or a complete wall, (2) in the presence of distinct visual cues, room cues, or in the absence of visual cues (infrared light), and (3) in the presence of configurations of visual and tactile cues. Mice were generally less active in the presence of salient cues and formed home bases near those cues. In addition, movement speed, path distribution, and the number and length of stops were modulated by contextual cues. With repeated tests, mice favored tactile cues over visual cues as their home base locations. Although responses to cues were robust over test days, conditioning to context was generally weak. That the exploratory behavior of mice is affected by experience and context provides insights into performance variability and may prove useful in investigating the genetic and neural influences on mouse behavior. (c) 2006 Elsevier Inc. All rights reserved.