Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit
Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit
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DOI：
10.1093/ndt/gfh137
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发表时间：
2004-06-01
影响因子：
6.1
通讯作者：
Ross, C
中科院分区：
文献类型：
--
作者：
Torpey, N;Barker, T;Ross, C
背景。急性肾小管间质性肾炎（TIN）是引起急性肾功能衰竭的重要原因，常由药物过敏引起。本研究的目的是在未选择的患者队列中确定间质性肾炎的病因，并确定通常与之相关的药物。对1995年至1999年间连续296例患者的肾活检结果进行了单中心回顾性分析。24例（8.1%）活检发现急性TIN。14例推测与药物相关的TIN中有8例可归因于质子泵抑制剂奥美拉唑和兰索拉唑。这两例兰索拉唑相关TIN是该药物首次报道的病例。本文描述了这些患者的表现和对治疗的良好反应。药物是研究人群间质性肾炎最常见的原因。最常与间质性肾炎相关的药物是质子泵抑制剂奥美拉唑和兰索拉唑。
Background. Acute tubulo-interstitial nephritis (TIN) is an important cause of acute renal failure, and is often caused by hypersensitivity to drugs. The aim of this study was to determine the aetiology of interstitial nephritis among an unselected cohort of patients, and to identify those drugs commonly implicated.Methods. A single-centre retrospective analysis was carried out of renal biopsy results from 296 consecutive patients between 1995 and 1999.Results. Acute TIN was identified in 24 (8.1%) biopsies. Eight out of 14 cases with presumed drug-related TIN could be attributed to the proton pump inhibitors omeprazole and lansoprazole. The two cases of lansoprazole-associated TIN are the first to be reported with this drug. The presentation and favourable response to treatment of these patients are described.Conclusion. Drugs are the most common cause of interstitial nephritis in the population studied. Those drugs most commonly associated with interstitial nephritis were the proton pump inhibitors omeprazole and lansoprazole.