Benzodiazepine receptor: demonstration in the central nervous system
Benzodiazepine receptor: demonstration in the central nervous system
复制标题
苯二氮卓受体：在中枢神经系统中的表现
DOI：
10.1126/science.918669
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发表时间：
1977
期刊：
影响因子：
56.9
通讯作者：
T. Okada
中科院分区：
文献类型：
--
作者：
H. Möhler;T. Okada
安定是一种强效次要镇静剂，与中枢神经系统中专门存在的特定苯二氮卓类受体具有高亲和力结合。受体主要定位于突触膜部分。与受体的结合是立体特异性的。各种苯二氮卓类药物对受体的竞争与其药理学效力密切相关。
Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.