Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat.
Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat.
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乙酰唑胺对猫腹髓表面引起的心肺作用。
DOI：
10.1113/jphysiol.1990.sp017939
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Guertzenstein,PG
中科院分区：
文献类型：
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作者：
Andreatta-vanLeyen,S;Averill,DB;Guertzenstein,PG
1.在α-氯醛糖麻醉猫中，乙酰唑胺在脑干与甘氨酸敏感区、中间化学敏感区和可能的C1儿茶酚胺能神经元共延的区域抑制碳酸酐酶，导致低血压、心动过缓和中枢呼吸驱动抑制。2.这些反应是浓度依赖性的，并且当酶底物（CO2）升高时仍然可以观察到。因此，在高碳酸血症和正常碳酸血症条件下，当乙酰唑胺局部应用于甘氨酸敏感区域时，观察到动脉血压、心率和呼吸率的相似反应。3.为了进一步研究外周压力、化学和心肺受体对这些反应的作用，在三种不同条件下将乙酰唑胺局部应用于甘氨酸敏感区域：完整的胆囊胺麻痹（5 mg kg-1 h-1）和人工通气（A）、去窦弓神经（B）和去窦弓神经+双侧迷走神经切断猫（C）。在所有条件下，观察到类似的反应。动脉血压下降为75 +/-11（A）、90 +/-13（B）和75 +/-9 mmHg（C）。乙酰唑胺给药期间的心率变化分别为-23 +/-6、-20 +/-8和-26 +/-6次/min-1。呼吸频率降低为9 +/-2（A）、11 +/-2（B）和11 +/-2次呼吸min-1（C）。4.数据表明，乙酰唑胺局部应用的反应主要是由于其在甘氨酸敏感区的中枢作用，不受外周压力感受器和化学感受器输入的影响。
1. Inhibition of carbonic anhydrase by acetazolamide in alpha‐chloralose‐anaesthetized cats, in a region of the brain stem co‐extensive with the glycine‐sensitive area, intermediate chemosensitive area, and probably C1 catecholaminergic neurones produces hypotension, bradycardia and depression of the central respiratory drive. 2. These responses are concentration dependent, and can still be observed when the enzyme substrate (CO2) is elevated. Therefore, in both the hypercapnic and the normocapnic condition, similar responses in arterial blood pressure, heart rate and respiratory rate are observed when acetazolamide is topically applied to the glycine‐sensitive area. 3. To investigate further the contribution of peripheral baro‐, chemo‐ and cardiopulmonary receptors to these responses, acetazolamide was topically applied to the glycine‐sensitive area under three different conditions: intact gallamine‐paralysed (5 mg kg‐1 h‐1) and artificially ventilated (A), sinoaortic denervated (B), and sinoaortic denervated plus bilaterally vagotomized cats (C). Under all conditions, similar responses were observed. The fall in arterial blood pressure was 75 +/‐ 11 (A), 90 +/‐ 13 (B), and 75 +/‐ 9 mmHg (C). Changes in heart rate during acetazolamide application were ‐23 +/‐ 6, ‐20 +/‐ 8, and ‐26 +/‐ 6 beats min‐1, respectively. The decreases in respiratory rate were 9 +/‐ 2 (A), 11 +/‐ 2 (B), and 11 +/‐ 2 breaths min‐1 (C). 4. The data indicate that the responses to topical application of acetazolamide are mainly due to its central action at the glycine‐sensitive area and are not influenced by peripheral baroreceptor and chemoreceptor inputs.