Reference values of aortic pulse wave velocity in the elderly
Reference values of aortic pulse wave velocity in the elderly
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DOI：
10.1097/hjh.0b013e32830e4932
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发表时间：
2008-11-01
影响因子：
4.9
通讯作者：
Benetos, Athanase
中科院分区：
文献类型：
--
作者：
Alecu, Cosmin;Labat, Carlos;Benetos, Athanase
背景：主动脉脉搏波速度（AoPWV）增加是心血管疾病发病率和死亡率的独立预测因子。然而，对于定义正常值或参考值，没有普遍接受的限值。本研究的目的是定义AoPWV的参考值。患者和方法AoPWV进行了评估，使用压平眼压计（PulsePen设备）在社区生活的流动人口455人，年龄60 - 75岁。AoPWV在一组206名无高血压或糖尿病的人中进行了研究，称为“参考值组”（RVG），并在一组249名高血压或糖尿病患者中进行了研究，称为高血压糖尿病组（HDG）。结果RVG组平均AoPWV为8.7 ± 2.3m/s，高血压合并糖尿病组为10.2 ± 2.5m/s（P < 0.0001）。在RVG中，三个年龄亚组的中位AoPWV为：60-64岁组8.0 m/s（7.6-8.5），65-69岁组8.0 m/s（7.5-9.0），70-75岁组9.0 m/s（7.9-9.5）（各组间NS）。在整个RVG中，样本的AoPWV的第75和第95百分位数的上限分别为10和13 m/s，没有性别差异。结论在60-75岁的老年人中，AoPWV值低于10 m/s，用PulsePen设备测量，可以被认为是正常值。10-13 m/s的值可以被认为是“高正常”或“边界”，而AoPWV高于13 m/s则明显升高。这项研究首次在老年人中提供了AoPWV的参考值。J Hypertens 26：2207-2212（c）2008 Wolters Kluwer Health垂直杆Lippincott威廉姆斯& Wilkins。
Background Increased aortic pulse wave velocity (AoPWV) is an independent predictor of cardiovascular morbidity and mortality. There are, however, no generally accepted limits for defining the normal or reference values. The aim of the present study was to define reference values for AoPWV.Patients and methods AoPWV was assessed using applanation tonometry (PulsePen device) in a community living ambulatory population of 455 individuals aged 60 75 years. AoPWV was studied in a group of 206 individuals without hypertension or diabetes, called the 'reference-values group' (RVG), and in a group of 249 individuals with hypertension or diabetes, called the hypertension-diabetes group (HDG). The 95th percentile of the samples was used to determine the upper limit of AoPWV reference values.Results Mean AoPWV was 8.7 +/- 2.3 m/s in the RVG and 10.2 +/- 2.5 m/s in the hypertension-diabetes group (P < 0.0001). In the RVG, median AoPWV in the three age subgroups was 8.0 m/s (7.6-8.5) in the 60-64-, 8.0 m/s (7.5-9.0) in the 65-69- and 9.0 m/s (7.9-9.5) in the 70-75-year-old group (NS among groups). In the entire RVG, the upper bounds of the 75th and the 95th percentile of the sample's AoPWV were 10 and 13 m/s, respectively, with no difference between sexes.Conclusion In elderly individuals of 60-75 years, an AoPWV value below 10 m/s, measured with the PulsePen device, can be considered as a normal value. Values of 10-13 m/s can be considered as 'high normal' or 'borderline', whereas an AoPWV above 13 m/s is frankly elevated. This study provides, for the first time in the elderly, reference values of AoPWV. J Hypertens 26: 2207-2212 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.