Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease
Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease
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DOI：
10.3892/etm.2018.6785
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发表时间：
2018-12-01
影响因子：
2.7
通讯作者：
Zhang, Fengling
中科院分区：
文献类型：
--
作者：
Fu, Xiang;Zhang, Fengling
慢性阻塞性肺疾病(COPD)是导致慢性发病率和死亡率的最常见原因。然而，COPD的分子机制在很大程度上仍不清楚。本研究旨在探讨缺氧诱导因子1(HIF-1)、血管内皮生长因子(VEGF)及其受体2(R2)在慢性阻塞性肺疾病(COPD)中的表达规律。检测102例吸烟、COPD和非COPD患者肺组织中HIF-1、VEGF和VEGFR2的表达并进行定量。吸烟的COPD患者肺组织中HIF-1、VEGF和VEGFR2的表达明显高于吸烟非COPD患者和非吸烟非COPD患者。HIF-1的表达与VEGF、VEGFR2的表达呈正相关。此外，HIF-1、VEGF和VEGFR2的表达增加反映了COPD的病情严重程度。本研究的关键发现表明，HIF-1、VEGF和VEGFR2的高表达可能与COPD患者的肺功能下降和生活质量下降有关，从而导致COPD的疾病进展。
Chronic obstructive pulmonary disease (COPD) is the most common cause of chronic morbidity and mortality. However, the molecular mechanisms underlying COPD remain largely unknown. The purpose of the present study was to investigate the expression patterns of hypoxia-inducible factor 1 (HIF-1), vascular endothelial growth factor (VEGF), and VEGF receptor 2 (R2) in regard to the HIF-1 signaling pathway in COPD. The expressions of HIF-1, VEGF and VEGFR2 were examined and quantified in the human lung tissues of 102 subjects with a defined smoking status, with or without COPD. The expressions of HIF-1, VEGF and VEGFR2 were observed to be increased in the lung tissues collected from smoking COPD subjects when compared with those tissues from smoking subjects without COPD and non-smoking subjects without COPD. The expression of HIF-1 was shown to be positively associated with the expression of VEGF and VEGFR2. In addition, increased expression of HIF-1, VEGF and VEGFR2 reflected the disease severity of COPD. The key findings obtained from the present study indicated that high expression of HIF-1, VEGF and VEGFR2 may be associated with decreased lung function and reduced quality of life, contributing to disease progression in COPD.