IL-12 enhances CD8 T cell homeostatic expansion
IL-12 enhances CD8 T cell homeostatic expansion
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DOI：
10.4049/jimmunol.166.9.5515
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发表时间：
2001-05-01
影响因子：
4.4
通讯作者：
Jameson, SC
中科院分区：
文献类型：
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作者：
Kieper, WC;Prlic, M;Jameson, SC
T淋巴细胞池的大小是通过调节T细胞的产生、增殖和存活来维持的。在T淋巴细胞减少环境的压力下，成熟的幼稚T细胞在缺乏Ag的情况下开始增殖，这一过程被称为稳态扩张。稳态扩张涉及TCR对自身肽/MHC配体的识别，但对调节这一过程的可溶性因子知之甚少。我们发现IL-12显著增强了CD8 T细胞的稳态增殖。相反，IL-2对稳态扩张没有有益作用，事实上。抑制IL-12诱导的T细胞扩增。使用基因靶向小鼠，我们发现IL-12直接作用于T细胞以增强稳态扩张，但IL-12不能超越稳态扩张中TCR与自身肽/MHC配体相互作用的要求。这些数据表明，炎症细胞因子可能调节淋巴细胞减少后的T细胞稳态，并对T细胞库和自身免疫的调节有影响。
The size of the T lymphocyte pool is maintained by regulation of T cell production, proliferation, and survival. Under the pressure of a T lymphopenic environment, mature naive T cells begin to proliferate in the absence of Ag, a process called homeostatic expansion. Homeostatic expansion involves TCR recognition of self peptide/MHC ligands, but less is known about the soluble factors that regulate this process. Here we show that IL-12 dramatically enhanced the homeostatic proliferation of CD8 T cells. In contrast, IL-2 had no beneficial effect on homeostatic expansion and, in fact. inhibited T cell expansion induced by IL-12. Using gene-targeted mice, we showed that IL-12 acted directly on the T cells to enhance homeostatic expansion, but that IL-12 cannot override the requirement for TCR interaction with self peptide/MHC ligands in homeostatic expansion. These data indicate that inflammatory cytokines may modulate T cell homeostasis after lymphopenia and have implications for regulation of the T cell repertoire and autoimmunity.