Follicle-stimulating isohormones: characterization and physiological relevance.
Follicle-stimulating isohormones: characterization and physiological relevance.
复制标题
DOI：
10.1210/edrv-16-6-765
复制
发表时间：
1995-12
影响因子：
20.3
通讯作者：
Alfredo Ulloa-Aguirre;A. Midgley;I. Beitins;I. Beitins;Vasantha Padmanabhan
中科院分区：
文献类型：
--
作者：
Alfredo Ulloa-Aguirre;A. Midgley;I. Beitins;I. Beitins;Vasantha Padmanabhan
I.卵泡刺激素（FSH）是由垂体前叶产生的主要激素之一，参与调节和维持基本的生殖过程，如配子发生，卵泡发育和排卵（1-4）。与其他糖蛋白激素一样，FSH作为一个同功激素家族存在，已在包括人类在内的几种哺乳动物的垂体前叶、血清和尿液中鉴定出（5-10）（表1）。这些亚型的寡糖结构不同，包括末端唾液酸化和/或硫酸化程度（5，7，9）。由此产生的酸碱电荷差异提供了分离的主要基础，所鉴定的异构体的数量通常是所采用的分离技术的分辨率的函数。这些亚型的结构差异改变了它们的MCR以及生物学和免疫学效价关系（6-8）。因此，性腺内的靶组织暴露于循环系统的混合物中。
I. Introduction FOLLICLE-stimulating hormone (FSH), one of the major hormones produced by the anterior pituitary gland, is involved in the regulation and maintenance of essential reproductive processes, such as gametogenesis, follicular development, and ovulation (1–4). Like other glycoprotein hormones, FSH exists as a family of isohormones which have been identified within the anterior pituitary, serum, and urine of several mammalian species, including man (5–10) (Table 1). These isoforms differ in their oligosaccharide structures, including the degree of terminal sialylation and/or sulfation (5, 7, 9). The resulting acidic-basic charge differences provide the major basis for separation, with the number of isoforms identified often being a function of the resolution of the separation technique employed. Structural differences in these isoforms alter their MCRs and biological and immunological potency relationships (6–8). Consequently, target tissues within the gonads are exposed to a mixture of circulati...