Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.
Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.
复制标题
替代耐受性对猪心脏异种移植物血管排斥的影响。
DOI：
10.1097/00007890-200001270-00007
复制
发表时间：
2000
期刊：
影响因子：
6.2
通讯作者：
Beschorner,WE
中科院分区：
文献类型：
--
作者：
Sudan,DL;Radio,SJ;MatamorosJr,A;Johnson,ND;Shearon,CC;Glogowski,KR;Hill,AC;Goertzen,TC;Fox,IJ;Langnas,AN;Beschorner,WE
Background.Organ xenografts are fulminantly rejected by antibody-mediated vascular rejection. Surrogate tolerogenesis (ST), the induction of tolerance within the donor, is effective with aorta xenografts. This preliminary study assesses the effect of ST on preformed antibodies and rejection of porcine heart xenografts.Methods.Tolerance to the donor pig was induced by infusing recipient marrow into fetal pigs. Later, pig splenocytes were transfused and heterotopic pig hearts transplanted using chimeric or nonchimeric pigs. Anti-pig antibodies were assessed.Results.With ST alone, xenografts developed cellular rejection at 4–6 days, whereas control grafts developed vascular rejection at 3–4 days (cellular vs. vascular, P< 0.03). There was a reduction in preformed antibodies (P< 0.03). ST combined with moderate cyclosporine prevented rejection at 9+ and 25 days in sensitized recipients compared with vascular rejection at 0.5–2 days for controls (P< 0.07).Conclusions.ST seems to provide protection against vascular rejection. The cellular rejection seems sensitive to cyclosporine.
