Lymphoproliferative responses to antigens mediated by human pulmonary alveolar macrophages.
Lymphoproliferative responses to antigens mediated by human pulmonary alveolar macrophages.
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对人肺泡巨噬细胞介导的抗原的淋巴细胞增殖反应。
DOI：
10.5555/uri:pii:002221437790018x
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Twomey
中科院分区：
文献类型：
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作者：
A. Laughter;R. Martin;J. Twomey
我们评估了人肺泡巨噬细胞（PAM）介导（3 H）-胸苷掺入的单核细胞严重耗尽的血液淋巴细胞时，刺激可溶性微生物和同种异体淋巴细胞抗原的能力。来自非吸烟者或血液单核细胞的低浓度（小于2%）PAM不支持最佳应答。总的来说，在大于或等于10%的浓度下，来自非吸烟者的PAM支持比单核细胞更高的应答。在小于或等于10%的浓度下，来自重度吸烟者的PAM比来自非吸烟者的类似浓度的PAM介导显著更少的掺入（p小于0.05）。研究结果表明，PAM的健康的不吸烟者是功能上有能力的巨噬细胞在介导淋巴细胞增殖的文化刺激抗原。这种经典的巨噬细胞功能因吸烟而受损。
We evaluated the ability of human pulmonary alveolar macrophages (PAMs) to mediate (3H)-thymidine incorporation by blood lymphocytes severely depleted of monocytes when stimulated with soluble microbial and allogeneic lymphocyte antigens. Low (less than 2%) concentrations of PAM's from nonsmokers or blood monocytes did not support optimal responses. Over all, at greater than or equal to 10% concentrations, PAM's from nonsmokers supported higher responses than monocytes. At less than or equal to 10% concentrations, PAM's from heavy cigarette smokers mediated significantly less incorporation than did similar concentrations of PAM's from nonsmokers (p less than 0.05). The findings indicate that PAM's from healthy nonsmokers are functionally competent macrophages in terms of mediating lymphoproliferation in cultures stimulated with antigens. This classical macrophage function is impaired with cigarette smoking.