Expression of oxytocin receptor in diabetic rat penis
Expression of oxytocin receptor in diabetic rat penis
复制标题
糖尿病大鼠阴茎催产素受体的表达
DOI：
10.1111/j.1439-0272.2011.01255.x
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发表时间：
2012
期刊：
影响因子：
2.4
通讯作者：
Z. Ye
中科院分区：
文献类型：
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作者：
M. Li;T. Wang;S. Guo;K. Rao;J. Liu;Z. Ye
催产素受体（OTR）在体外和体内均在大鼠阴茎中表达并介导海绵体平滑肌的收缩，OTR能维持阴茎的消肿；然而，OTR在糖尿病大鼠阴茎中的表达尚不清楚。本研究研究了OTR在糖尿病大鼠阴茎中的表达。实验大鼠随机分为对照组和STZ -糖尿病大鼠组。分别用实时定量PCR、Western blotting和免疫组织化学检测mRNA和蛋白的表达。在电刺激海绵体神经后，通过测量海绵体内压力来评估勃起功能。与对照组相比，糖尿病大鼠组OTR mRNA和蛋白表达明显升高。与对照组相比，糖尿病大鼠勃起功能明显降低。我们的数据显示，OTR在糖尿病大鼠组的表达显著增加，OTR可能参与糖尿病勃起功能障碍的发生发展。
Oxytocin receptor (OTR) expressed in the rat penis and mediated the contractility of the corpus cavernosum smooth muscle both in vitro and in vivo, and OTR could maintain penile detumescence; however, the expression of OTR in diabetic rat penis remains unknown. In the present study, we investigated the expression of OTR in diabetic rat penis. The experimental rats were randomly divided into control group and STZ‐diabetic rats group. The expressions of mRNA and protein were examined by real‐time quantitative PCR, Western blotting and immunohistochemistry respectively. Erectile function was evaluated by measuring intracavernous pressure following electrostimulation of the cavernous nerves. mRNA and protein expression of OTR significantly increased in diabetic rats group compared with the control group. Erectile function of diabetic rats group significantly decreased compared with the control group. Our data showed that the expression of OTR significantly increased in diabetic rats group and OTR may involve in the development of diabetic erectile dysfunction.
Rho激酶介导缺氧诱导的细胞周期蛋白依赖性激酶抑制剂下调
DOI：
--
发表时间：
2006
期刊：
影响因子：
--
作者：
Kadowaki;M.;et. al.
通讯作者：
et. al.