Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.
复制标题
小鼠免疫球蛋白重链基因的多样性和连接片段紧密相连且方向相同：对连接机制的影响。
DOI：
10.1073/pnas.80.10.3030
复制
发表时间：
1983
影响因子：
11.1
通讯作者：
Tonegawa,S
中科院分区：
文献类型：
--
作者：
Wood,C;Tonegawa,S
通过对从重组噬菌体和粘粒文库中分离的DNA克隆的分子分析，我们将小鼠IG重链80和1个组氨酸酶5'之间的12个多样性（D）基因片段定位到4个连接（JH）基因片段。所有识别的D和JH片段都处于相同的5 '-3'方向。这些研究结果的意义与IG基因片段的连接机制进行了讨论。
We have mapped 12 diversity (D) gene segments of mouse Ig heavy chains between 80 and 1 kilobases 5' to the four joining (JH) gene segments by molecular analysis of DNA clones isolated from recombinant phage and cosmid libraries. All identified D and JH segments are in the same 5'-3' orientation. The significance of these findings with respect to the joining mechanism for Ig gene segments is discussed.