Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo-controlled trial in abstinent alcoholics
Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo-controlled trial in abstinent alcoholics
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DOI：
10.1002/mnfr.201200676
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发表时间：
2013-06-01
影响因子：
5.2
通讯作者：
Minelli, Andrea
中科院分区：
文献类型：
--
作者：
Barbadoro, Pamela;Annino, Isidoro;Minelli, Andrea
行为困扰和下丘脑-垂体-肾上腺皮质（HPA）轴功能障碍在酒精滥用中起核心作用。Omega-3脂肪酸被认为具有抗应激、调节HPA反应的作用，但对乙醇成瘾的可能保护作用尚未探索。一项随机、双盲、安慰剂对照试验在接受住宅康复计划的男性酗酒者中进行，以评估补充三周提供二十碳五烯酸（60毫克/天）和二十二碳六烯酸（252毫克/天）的鱼油对感知压力/焦虑和HPA活性的影响，通过测量不同时间（0730小时、1130小时、1600小时、2000小时和2400小时）的唾液基础皮质醇水平和特里尔社会压力测试的急性皮质醇反应来评估。结果显示，在补充药物的受试者中，压力/焦虑等级的降低前后伴随着全天皮质醇基础水平的降低；安慰剂组无明显变化。在干预结束时，应激引起的皮质醇反应的幅度和持续时间在两组之间没有差异；然而，皮质醇反应的峰值在补充的受试者中是暂时预期的。综上所述，增加omega-3摄入量可以减轻戒酒者的痛苦症状和基础皮质醇分泌，从而为提高乙醇成瘾者康复计划的疗效提供了有效的辅助措施。
Behavioral distress and dysfunctions of hypothalamic-pituitary-adrenocortical (HPA) axis play a central role in alcohol abuse. Omega-3 fatty acids are proposed as having antistress, regulatory effects on HPA responsiveness, but a possible protective role in ethanol addiction is unexplored.A randomized, doubleblind, placebo-controlled trial was performed in male alcoholics undergoing residential rehabilitation program, to evaluate the effects of 3-week supplementation with fish-oil providing eicosapentaenoic (60 mg/day) and docosahexaenoic acid (252 mg/day) on perceived stress/anxiety and HPA activity, assessed by measuring saliva basal cortisol levels at various daytimes (0730 h, 1130 h, 1600 h, 2000 h, and 2400 h) and the acute cortisol response to Trier Social Stress Test.Results showed that in supplemented subjects, before versus after decrease of stress/anxiety ratings was accompanied by reduction of cortisol basal levels throughout the day; no changes were observed in placebo group. At the end of intervention, amplitude, and duration of stress-evoked cortisol response did not differ between groups; however, the peak of cortisol response was temporally anticipated in supplemented subjects. In conclusion, an elevated omega-3 intake may reduce distress symptoms and basal cortisol secretion in abstinent alcoholics, thus providing a valid subsidiary measure to increase the efficacy of rehabilitation programs in ethanol addicts.