Comparing buprenorphine induction experience with heroin and prescription opioid users
Comparing buprenorphine induction experience with heroin and prescription opioid users
复制标题
DOI：
10.1016/j.jsat.2011.12.009
复制
发表时间：
2012-10-01
影响因子：
3.9
通讯作者：
Ling, Walter
中科院分区：
文献类型：
--
作者：
Nielsen, Suzanne;Hillhouse, Maureen;Ling, Walter
处方阿片类药物依赖性治疗表现越来越普遍;然而，关于阿片类药物依赖人群治疗的大多数研究都是在海洛因使用者中进行的。该次要数据分析的目的是比较167名海洛因和61名PO使用者的丁丙诺啡诱导经验。结果表明，尽管两组在一些基线特征上存在差异，但两组之间的许多关键诱导经验变量具有可比性。与PO使用者相比，海洛因使用者在诱导前临床阿片类戒断量表（COWS）评分（p = .014）和诱导后COWS评分（p = .008）显著较高。在自我报告的渴望和戒断评分、第一天的平均丁丙诺啡剂量或第一周结束时的保留方面，未发现组间差异。这项研究的结果表明，现有的丁丙诺啡诱导海洛因使用者的做法似乎是同样有效的PO用户。(C)2012 Elsevier Inc. All rights reserved.
Prescription opioid (PO)-dependent treatment presentations are becoming increasingly common; however, most research on the treatment of opioid-dependent populations has been conducted in heroin users. The aim of this secondary data analysis was to compare the buprenorphine induction experience of 167 heroin and 61 PO users. Results demonstrate that although the groups differed on some baseline characteristics, many of the key induction experience variables were comparable between the groups. Heroin users were found to have significantly higher preinduction Clinical Opiate Withdrawal Scale (COWS) scores (p = .014) and postinduction COWS score (p = .008) compared with the PO users. No differences between groups were found for self-reported craving and withdrawal scores, mean buprenorphine dose on Day I, or retention at the end of the first week. The findings of this study suggest that existing buprenorphine induction practices developed for heroin users appear to be equally effective with PO users. (C) 2012 Elsevier Inc. All rights reserved.