Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone.
Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone.
复制标题
通过下丘脑内输注合成促黄体生成素释放激素来增强脊柱前凸行为。
DOI：
10.1159/000122481
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发表时间：
1976
影响因子：
4.1
通讯作者：
M. Foreman
中科院分区：
文献类型：
--
作者：
R. L. Moss;M. Foreman
将生理盐水和促黄体激素释放激素（LRH）注入内侧视前区（MPOA）、弓状核（ARC）、下丘脑外侧区（LHA）和大脑皮质（CC），研究对雌酮（E）致敏的卵巢切除（OVX）雌性大鼠性行为的影响。对每只已知性活跃的插管OVX雌性动物以太低剂量的E引发，以启动一致的交配行为。LRH输注无论是MPOA或ARC促进性行为所测量的脊柱前凸安装（L/M）的比例; LRH输注在LHA或CC，以及盐水输注在所有的神经网站，是无效的，在启动可比的行为模式。结果与利用全身LRH注射的结果一致，并支持LRH可能直接作用于神经组织以增强雌性大鼠的脊柱前凸行为的观点。
Saline and luteinizing hormone-releasing hormone (LRH) were infused into the medial preoptic area (MPOA), arcuate nucleus (ARC), lateral hypothalamic area (LHA) and the cerebral cortex (CC), and the effects on sexual behavior were studied in estrone- (E-) primed ovariectomized (OVX) female rats. Each cannulated, OVX female known to be sexually active was primed with E in doses too low to initiate consistent mating behavior. LRH infusion in either the MPOA or ARC faciliated sexual behavior as measured by the lordosis-to-mount (L/M) ratio; LRH infusion in the LHA or CC, as well as saline infusion in all neural sites, was ineffective in initiating comparable behavior patterns. The results concur with findings utilizing systemic LRH injections and support the notion that LRH may act directly on neural tissue to potentiate lordosis behavior in the female rat.