Inhibition of cancer antioxidant defense by natural compounds.
Inhibition of cancer antioxidant defense by natural compounds.
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DOI：
10.18632/oncotarget.13723
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发表时间：
2017-02-28
期刊：
影响因子：
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通讯作者：
Bielawski KP
中科院分区：
文献类型：
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作者：
Sznarkowska A;Kostecka A;Meller K;Bielawski KP
所有经典的非手术抗癌方法，如化疗、放疗或光动力疗法，都是通过诱导严重的氧化应激来杀死癌细胞。即使是严酷的化疗和放疗仍然是癌症治疗的黄金标准，识别出增强其选择性的无毒化合物将有助于降低剂量、减少副作用和患第二种癌症的风险。许多天然产物能够通过限制癌细胞的抗氧化能力，使癌细胞对化疗和放疗引起的氧化应激敏感。阻断肿瘤中的抗氧化防御会降低其平衡氧化损伤的能力并导致细胞死亡。但我们应该记住，同一种天然化合物通常会同时发挥抗氧化和促氧化特性，具体取决于使用的浓度、细胞类型、暴露时间和环境条件。在这里，我们全面概述了抑制癌细胞主要抗氧化防御机制的天然产物，并讨论了它们在临床应用中的潜力。
All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough chemo- and radiotherapy are still a gold standard in cancer treatment, the identification of non-toxic compounds that enhance their selectivity, would allow for lowering their doses, reduce side effects and risk of second cancers. Many natural products have the ability to sensitize cancer cells to oxidative stress induced by chemo- and radiotherapy by limiting antioxidant capacity of cancer cells. Blocking antioxidant defense in tumors decreases their ability to balance oxidative insult and results in cell death. Though one should bear in mind that the same natural compound often exerts both anti-oxidant and pro-oxidant properties, depending on concentration used, cell type, exposure time and environmental conditions. Here we present a comprehensive overview of natural products that inhibit major antioxidant defense mechanisms in cancer cells and discuss their potential in clinical application.