Nitric oxide and cancer: a review.
Nitric oxide and cancer: a review.
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DOI：
10.1186/1477-7819-11-118
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发表时间：
2013-05-30
影响因子：
3.2
通讯作者：
Joshi V
中科院分区：
文献类型：
--
作者：
Choudhari SK;Chaudhary M;Bagde S;Gadbail AR;Joshi V
一氧化氮（NO）是一种普遍存在的水溶性自由基气体，在各种生理和病理过程中起着关键作用。在过去的几十年里，NO已经成为致癌和肿瘤生长进展中感兴趣的分子。然而，在理解其在癌症生物学中的作用方面存在相当大的争议和混乱。据说，它既具有杀瘤作用，也具有促瘤作用，这取决于它的时间、位置和浓度。NO被认为可以调节不同的癌症相关事件，包括血管生成、细胞凋亡、细胞周期、侵袭和转移。另一方面，它也是一种潜在的抗肿瘤药物。目前正在研究如何操纵该分子的体内生产和外源性递送以获得治疗效果。然而，基于NO的癌症治疗和预防新策略的开发需要进一步的验证和实验/临床试验。本综述通过使用相关搜索词和文献综述进行在线MEDLINE搜索，讨论了NO在癌症中的作用范围。一氧化氮在乳腺癌、宫颈癌、胃癌、结直肠癌和头颈癌等不同癌症中的作用机制。它还提供了对一氧化氮的二分性的洞察，并讨论了其在癌症预防和治疗方面的新治疗应用。
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration. NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On the other hand, it is also emerging as a potential anti-oncogenic agent. Strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain are being investigated. However, further validation and experimental/clinical trials are required for development of novel strategies based on NO for cancer treatment and prevention. This review discusses the range of actions of NO in cancer by performing an online MEDLINE search using relevant search terms and a review of the literature. Various mechanisms by which NO acts in different cancers such as breast, cervical, gastric,colorectal, and head and neck cancers are addressed. It also offers an insight into the dichotomous nature of NO and discusses its novel therapeutic applications for cancer prevention and treatment.
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影响因子：
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作者：
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