Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation
Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation
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DOI：
10.1016/j.neurobiolaging.2005.08.021
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Craft, S
中科院分区：
文献类型：
--
作者：
Craft, S
胰岛素在记忆和大脑功能的其他方面起着重要作用。胰岛素抵抗综合征。以慢性外周胰岛素升高、胰岛素活性降低和脑胰岛素水平降低为特征的阿尔茨海默病与年龄相关的记忆障碍和阿尔茨海默病（AD）相关。我们的工作集中在特定的机制，通过这种关联是伪造的，包括外周高胰岛素血症对记忆，炎症和β-淀粉样肽的调节，在AD病理生理学中起着关键作用的影响。我们的数据表明，过量的胰岛素引起A β和炎症因子水平的同步增加。年龄和肥胖会加剧这种影响。这一连串的事件可能会对记忆产生有害的影响。预防或纠正胰岛素异常的治疗可能对患有年龄相关记忆障碍和AD的成年人有治疗益处。(c)2005年由Elsevier Inc.出版
Insulin plays an important role in memory and other aspects of brain function. The insulin resistance syndrome. characterized by chronic peripheral insulin elevations, reduced insulin activity, and reduced brain insulin levels, is associated with age-related memory impairment and g Alzheimer's disease (AD). Our work has focused on specific mechanisms through which this association is forged, including the effects of peripheral hyperinsulinemia on memory, inflammation, and regulation of the beta-amyloid peptide that plays a key role in AD pathophysiology. Our data suggest that excessive insulin invokes synchronous increases in levels of A beta and inflammatory agents. effects that are exacerbated by age and obesity. This constellation of events may have deleterious effects on memory. Treatments focused on preventing or correcting insulin abnormalities may be of therapeutic benefit for adults with age-related memory impairment and AD. (c) 2005 Published by Elsevier Inc.