The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis
The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis
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DOI：
10.1007/s10875-007-9125-8
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发表时间：
2008-01-01
影响因子：
9.1
通讯作者：
Nakano, Hiroshi
中科院分区：
文献类型：
--
作者：
Arisawa, Tomiyasu;Tahara, Tomomitsu;Nakano, Hiroshi
我们研究了溃疡性结肠炎（UC）与IL-17 A（rs 2275913，G-197 A）和IL-17 F（rs763780，7488 T/C）基因多态性的关系。采用多重PCR-SSCP方法检测基因多态性。IL-17 A和7488 T等位基因的数目与UC的发生发展显著相关。UC组-197A/A和7488 T/T基因型频率显著高于非UC组。校正分析显示-197A和7488 T等位基因是UC发生的独立危险因素。此外，这两种多态性与全结肠炎表型显著相关。-197A等位基因与慢性复发表型显著相关，-197A/A纯合子在激素依赖患者中更常见，而7488 T等位基因与慢性持续表型相关。本研究首次证明IL-17 A（-197A）和IL-17 F（7488 T）等位基因可能独立影响UC的易感性和病理生理学特征。
We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.