White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging analysis in a voxelwise approach.
White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging analysis in a voxelwise approach.
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DOI：
10.3389/fneur.2012.00121
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发表时间：
2012
影响因子：
3.4
通讯作者：
Cendes F
中科院分区：
文献类型：
--
作者：
Fonseca Vde C;Yasuda CL;Tedeschi GG;Betting LE;Cendes F
背景资料：扩散张量成像（DTI）允许通过量化组织中水分子的扩散和方向来分析微观结构的变化。我们使用分数各向异性（FA）地图比较患者和对照组之间的WM的完整性。本研究的目的是探讨额叶癫痫继发局灶性皮质发育不良（FCD）患者的WM异常。材料与方法：我们纳入了31名对照组（12名女性，33.1 ± 9.6岁，平均值±标准差）和22名患者（11名女性，30.4 ± 10.0岁），从我们的门诊招募。他们有额叶癫痫的临床和EEG诊断，继发于MRI检测到的FCD。患者和对照组接受3 T MRI，包括DTI序列，在32个方向获得，B值为1000 s/mm 2。为了处理DTI，我们使用了以下软件：MRIcroN和FSL/TBSS（tract-based spatial statistics）。我们使用了无阈值聚类增强，显著性为p < 0.05，完全校正了跨空间的多重比较。结果如下：在患者的两个半球中确定了FA减少的区域，主要是额叶、扣带回和小钳（p = 0.014）、尾状核和丘脑前放射（p = 0.034）、上级纵束（p = 0.044）、钩束和下额枕束（p = 0.042）。结论：我们的研究结果表明，广泛的模式WM微结构异常延伸到MRI（额叶）上看到的主要病变之外，这可能与频繁的癫痫发作或MRI不可见的FCD部分的程度有关。
Background: Diffusion tensor imaging (DTI) allows the analysis of changes in microstructure, through the quantification of the spread and direction of water molecules in tissues. We used fractional anisotropy (FA) maps to compare the integrity of WM between patients and controls. The objective of the present study was to investigate WM abnormalities in patients with frontal lobe epilepsy secondary to focal cortical dysplasia (FCD). Materials and Methods: We included 31 controls (12 women, 33.1 ± 9.6 years, mean ± SD) and 22 patients (11 women, 30.4 ± 10.0 years), recruited from our outpatient clinic. They had clinical and EEG diagnosis of frontal lobe epilepsy, secondary to FCD detected on MRI. Patients and controls underwent 3T MRI, including the DTI sequence, obtained in 32 directions and b value of 1000 s/mm2. To process the DTI we used the following softwares: MRIcroN and FSL/TBSS (tract-based spatial statistics). We used a threshold-free cluster enhancement with significance at p < 0.05, fully corrected for multiple comparisons across space. Results: Areas with FA reduction in patients were identified in both hemispheres, mainly in the frontal lobes, cingulum, and forceps minor (p = 0.014), caudate e anterior thalamic radiation (p = 0.034), superior longitudinal fasciculus (p = 0.044), uncinate fasciculus, and inferior fronto-occipital fasciculus (p = 0.042). Conclusion: Our results showed a widespread pattern of WM microstructural abnormalities extending beyond the main lesion seen on MRI (frontal lobe), which may be related to frequent seizures or to the extent of MRI-invisible portion of FCD.