Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo
Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo
复制标题
降钙素基因相关肽使骨骼肌小动脉对体内 P 物质脱敏
DOI：
10.1111/j.1476-5381.1988.tb11691.x
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发表时间：
1988
影响因子：
7.3
通讯作者：
P. Hedqvist
中科院分区：
文献类型：
--
作者：
A. Öhlén;N. Wiklund;M. Persson;P. Hedqvist
测试了降钙素基因相关肽 (CGRP) 与 P 物质对兔骨骼肌小动脉的体内作用可能存在的相互作用。 CGRP 和 P 物质均剂量依赖性地增加小动脉直径。然而，CGRP 预处理使小动脉对 P 物质不敏感，并且还阻止了通常在 P 物质后出现的白细胞和血小板聚集体的形成。这些结果表明，CGRP 除了其直接作用外，还可能充当 P 物质在神经源性炎症中作用的调节剂。
Calcitonin gene‐related peptide (CGRP) was tested for possible interactions with the effects of substance P on rabbit skeletal muscle arterioles in vivo. Both CGRP and substance P dose‐dependently increased arteriolar diameter. However, pretreatment with CGRP made the arterioles insensitive to substance P, and also prevented the formation of aggregates of leukocytes and platelets normally seen after substance P. These results suggest that CGRP, in addition to its direct effects, may act as a modulator of the effects of substance P in neurogenic inflammation.