PRESSURE-VOLUME BEHAVIOR OF THE UPPER AIRWAY
PRESSURE-VOLUME BEHAVIOR OF THE UPPER AIRWAY
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DOI：
10.1152/jappl.1986.61.3.912
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发表时间：
1986-09-01
影响因子：
3.3
通讯作者：
STROHL, KP
中科院分区：
文献类型：
--
作者：
FOUKE, JM;TEETER, JP;STROHL, KP
本研究旨在探讨上气道肌肉在呼吸努力过程中产生的力与上气道扩张之间的关系。在11只麻醉犬中，我们通过横断颈部气管并封闭鼻腔和口腔开口来隔离上气道（鼻、口、咽和喉区域）。在自主呼吸过程中，密封的上气道内的压力（用作扩张力的指标）在吸气过程中降低。在交替呼吸时，上气道对呼吸速度描记器开放，并且在吸气期间也发生了容量增加。再呼吸引起的进行性高氧高碳酸血症增加了压力和容量的变化幅度。在任何驱动水平下，峰值压力或容积均发生在吸气期间的同一点。在任何水平的驱动，容量和压力的变化增加与呼气末阻塞的气管。在再呼吸过程中的测量确定的力-容积关系进行了比较，压力-容积曲线进行被动充气的气道，而动物是呼吸暂停。呼吸暂停期间的相关性为1.06 ± 0.001。0.55（SD）ml/cmH 2 O，而来自再呼吸试验的力-容积关系为-1.09 . ±-。0.45 ml/cmH2O。我们的结论是，有一个对应的生产力和体积膨胀在上气道在积极的呼吸努力。
The study was performed to investigate the relationship between force generation and upper airway expansion during respiratory efforts by upper airway muscles. In 11 anesthetized dogs we isolated the upper airway (nasal, oral, pharyngeal, and laryngeal regions) by transecting the cervical trachea and sealing the nasal and oral openings. During spontaneous respiratory efforts the pressure within the sealed upper airway, used as an index of dilating force, decreased during inspiration. On alternate breaths the upper airway was opened to a pneumotachograph, and an increase in volume occurred, also during inspiration. Progressive hyperoxic hypercapnia produced by rebreathing increased the magnitude of change in pressure and volume. At any level of drive, peak pressure or volume occurred at the same point during inspiration. At any level of drive, volume and pressure changes increased with end-expiratory occlusion of the trachea. The force-volume relationship determined from measurements during rebreathing was compared with pressure-volume curves performed by passive inflation of the airway while the animal was apneic. The relationship during apnea was 1.06 .+-. 0.55 (SD) ml/cmH2O, while the force-volume relationship from rebreathing trials was -1.09 .+-. 0.45 ml/cmH2O. We conclude that there is a correspondence between force production and volume expansion in the upper airway during active respiratory efforts.