Sleep disturbance is associated with cardiovascular and metabolic disorders
Sleep disturbance is associated with cardiovascular and metabolic disorders
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DOI：
10.1111/j.1365-2869.2011.00990.x
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发表时间：
2012-08-01
影响因子：
4.4
通讯作者：
Gehrman, Philip R.
中科院分区：
文献类型：
--
作者：
Grandner, Michael A.;Jackson, Nicholas J.;Gehrman, Philip R.
现有的研究表明，睡眠时间与肥胖、糖尿病、心血管疾病和死亡率之间存在关联。睡眠障碍研究表明，睡眠呼吸暂停、失眠和其他睡眠障碍会增加心脏代谢疾病的风险，尤其是在睡眠时间缩短的情况下。本研究的目的是检查一般睡眠障碍（如入睡困难、保持睡眠或睡得太多，在全国范围内具有代表性的大样本中测量）与自我报告的心肌梗死、中风、冠状动脉疾病、糖尿病和肥胖史之间的关系。分析来自行为风险因素监测系统的数据。138201人获得完整资料。分层逻辑回归分析检查了人口、社会经济、医疗和心理因素调整前后的关联。在调整了人口统计学、社会经济和健康风险因素后，睡眠时间与肥胖（比值比(OR) = 1.18, P < 0.0005）、糖尿病（OR = 1.18, P < 0.005）、心肌梗死（OR = 1.36, P < 0.0005）、中风（OR = 1.22, P < 0.05）和冠状动脉疾病（OR = 1.59, P < 0.0005）相关。在包括身体健康在内的完全调整模型中，肥胖（OR = 1.14, P < 0.0005）、心肌梗死（OR = 1.23, P < 0.005）和冠状动脉疾病（OR = 1.43, P < 0.0005）之间仍然存在显著关系。睡眠障碍是肥胖、糖尿病、心肌梗死、中风和冠状动脉疾病的重要危险因素，且调整后对肥胖、心肌梗死和冠状动脉疾病的影响最为显著。这项研究表明，睡眠障碍是一种新的风险因素，可能是可以改变的。未来的研究应该确定睡眠干预是否可以减少睡眠障碍对心脏代谢的影响。
Existing research has demonstrated associations between sleep duration and obesity, diabetes, cardiovascular disease and mortality. Sleep disorders research has shown that sleep apnoea, insomnia and other sleep disorders confer risk for cardiometabolic disease, particularly in the presence of reduced sleep duration. The aim of the present study was to examine the associations between general sleep disturbance, operationalized as difficulty falling asleep, staying asleep, or sleeping too much as measured in a large, nationally representative sample, and self-reported history of myocardial infarction, stroke, coronary artery disease, diabetes and obesity. Data from the Behavioral Risk Factor Surveillance System were analysed. Complete data were available for 138 201 individuals. A hierarchical logistic regression analysis examined associations before and after adjustment for demographic, socioeconomic, medical and psychological factors. After adjusting for demographic, socioeconomic and health risk factors, sleep duration was associated with obesity [odds ratio (OR) = 1.18, P < 0.0005), diabetes (OR = 1.18, P < 0.005), myocardial infarction (OR = 1.36, P < 0.0005), stroke (OR = 1.22, P < 0.05) and coronary artery disease (OR = 1.59, P < 0.0005). In fully adjusted models that included physical health, significant relationships remained for obesity (OR = 1.14, P < 0.0005), myocardial infarction (OR = 1.23, P < 0.005) and coronary artery disease (OR = 1.43, P < 0.0005). Sleep disturbance is a significant risk factor for obesity, diabetes, myocardial infarction, stroke and coronary artery disease, and effects for obesity, myocardial infarction and coronary artery disease are the most robust after adjustment. This study demonstrates that sleep disturbance is a novel risk factor that is potentially modifiable. Future research should determine whether sleep intervention could reduce the cardiometabolic consequences of sleep disturbance.