Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies
Image derived input functions for dynamic High Resolution Research Tomograph PET brain studies
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DOI：
10.1016/j.neuroimage.2008.07.035
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发表时间：
2008-12-01
期刊：
影响因子：
5.7
通讯作者：
Boellaard, Ronald
中科院分区：
文献类型：
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作者：
Mourik, Jurgen E. M.;van Velden, Floris H. P.;Boellaard, Ronald
高分辨率研究断层扫描仪（HRRT）是一种专用的人脑正电子发射断层扫描仪（PET）。本研究的目的是验证使用图像导出输入函数（IDIF）作为替代动脉采样的HRRT人脑研究。为此，从3D普通泊松有序子集期望最大化（OP-OSEM）和基于重建的部分体积校正（PVC）OP-OSEM图像中提取IDIF，直接从感兴趣区域导出或使用扫描期间采集的手动样本进一步校准的IDIF用于动态[C-11]氟马西尼数据（n=6）。将IDIF获得的结果与使用血液采样器输入函数（BSIF）获得的结果进行比较。这些比较包括峰（0-3.3 min）和尾（3.3-55.0 min）的曲线下面积（AUC）。此外，还计算了每个受试者基于IDIF和BSIF的示踪动力学分析结果的斜率、截距和Pearson相关系数，发现从OP-OSEM图像中提取的校准IDIF的IDIF和BSIF之间的峰AUC比（0.83 +/- 0.21）良好。IDIF和图像的这种组合也提供了良好的斜率值（1.07 +/-0.11）。采用PVC OP-OSEM获得的分辨率提高，AUC比变为1.14 +/- 0.35，对于示踪剂动力学分析，斜率变为0.95 +/- 0.13。对于所有的重建，非校准IDIFs得到较差的结果（>61 +/- 34%高斜率）相比，校准IDIFs. Results的研究结果表明，使用IDIFs，提取OP-OSEM或PVC OP-OSEM图像，是可行的动态HRRT数据，从而避免了需要在线动脉采样。(C)2008年爱思唯尔公司All rights reserved.
The High Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. The aim of the present study was to validate the use of image derived input functions (IDIF) as an alternative for arterial sampling for HRRT human brain studies. To this end, IDIFs were extracted from 3D ordinary Poisson ordered subsets expectation maximization (OP-OSEM) and reconstruction based partial volume corrected (PVC) OP-OSEM images.IDIFs, either derived directly from regions of interest or further calibrated using manual samples taken during scans, were evaluated for dynamic [C-11]flumazenil data (n=6). Results obtained with IDIFs were compared with those obtained using blood sampler input functions (BSIF). These comparisons included areas under the curve (AUC) for peak (0-3.3 min) and tail (3.3-55.0 min). In addition, slope, intercept and Pearson's correlation coefficient of tracer kinetic analysis results based on IDIF and BSIF were calculated for each subject.Good peak AUC ratios (0.83 +/- 0.21) between IDIF and BSIF were found for calibrated IDIFs extracted from OP-OSEM images. This combination of IDIFs and images also provided good slope values (1.07 +/- 0.11). Improved resolution, as obtained with PVC OP-OSEM, changed AUC ratios to 1.14 +/- 0.35 and, for tracer kinetic analysis, slopes changed to 0.95 +/- 0.13. For all reconstructions, non-calibrated IDIFs gave poorer results (>61 +/- 34% higher slopes) compared with calibrated IDIFs.The results of this study indicate that the use of IDIFs, extracted from OP-OSEM or PVC OP-OSEM images, is feasible for dynamic HRRT data, thereby obviating the need for online arterial sampling. (C) 2008 Elsevier Inc. All rights reserved.