Influence of age and osteoporosis on calcaneus trabecular bone structure: a preliminary in vivo MRI study by quantitative texture analysis
Influence of age and osteoporosis on calcaneus trabecular bone structure: a preliminary in vivo MRI study by quantitative texture analysis
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DOI：
10.1016/j.mri.2003.07.007
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发表时间：
2004-02-01
影响因子：
2.5
通讯作者：
Meyer, ME
中科院分区：
文献类型：
--
作者：
Herlidou, S;Grebe, R;Meyer, ME
高分辨率磁共振成像技术的最新发展为非侵入性方法表征松质骨的结构开辟了新的前景。本研究对17名健康志愿者和6名骨质疏松患者进行了三维磁共振成像。使用两种不同的MR序列来评估MR采集对纹理分析结果的影响。使用四种自动纹理分析方法(灰度直方图、共生矩阵、游程长度和梯度矩阵)对图像进行分析，从而能够定量分析三个不同感兴趣区域(ROI)内的灰度强度和分布。纹理分析不是很常用，因为很难解释大量的计算参数。我们应用主成分分析(CFA)和层次升序分类(HAC)等多参数数据分析来确定相关参数，以区分三组图像(健康青年志愿者、健康绝经后患者和骨质疏松患者)。结果表明，如果所有患者的检查使用严格相同的采集序列，可以从跟骨MR图像中提取相关的纹理信息(取决于跟骨中的ROI定位)来评估骨质疏松症和年龄对骨小梁结构的影响。(C)2004 Elsevier Inc.保留所有权利。
Recent developments in high-resolution MR imaging techniques have opened up new perspectives for structural characterization of trabecular bone by non-invasive methods. In this study, 3-D MR imaging was performed on 17 healthy volunteers and 6 osteoporotic patients. Two different MR sequences were used to evaluate the impact on MR acquisition on texture analysis results. Images were analyzed with four automated methods of texture analysis (grey level histogram, cooccurrence, runlength and gradient matrices) enabling quantitative analysis of grey level intensity and distribution within three different regions of interest (ROI). Texture analysis is not very frequently used since the interpretation of the large number of calculated parameters is difficult. We applied multiparametric data analyses such as principal component analysis (CFA) and hierarchical ascending classification (HAC) to determine the relevant parameters to differentiate between three sets of images (healthy young volunteers, healthy postmenopaused and osteoporotic patients). The results suggest that relevant texture information (depending on the ROI localization in the calcaneus) can be extracted from calcaneus MR images to evaluate osteoporosis and age effects on trabecular bone structure if strictly the same acquisition sequences are used for all patients' examination. (C) 2004 Elsevier Inc. All rights reserved.